ブホルミンの品質試験と尿中排泄

概要

論文の詳細を見る
Buformin tablets of 5 Japanese brands (A,B,C,D,E) were tested for their pharmaceutical properties. Brand E had higher dissolution rate and shorter disintegration time than those of the other brands. Urinary excretion measurement of brand A was made in 31 diabetic patients and 4 healthy males after oral administration. In all the healthy males and most of diabetic patients, about 80% of the dose administered was excreted in urine with in 24 hours, as compared with about 30% in 2 diabetic patients. The correlation was investigated between urinary excretion of buformin and several clinical laboratory findings, and the following results were obtained : 1) A good correlation was observed between urinary excretion of buformin and creatinine clearance. 2) Quantity of biogenic amines after oral administration of buformin was decreased in comparison with that before the administration.
日本医療薬学会の論文
1982-12-20