市販消化酵素剤の胃溶部分のリパーゼ活性

概要

論文の詳細を見る
The effects of Fe ion on lipase activity of pancreatin (J.P.) and gastric soluble parts of five kinds of microorganism-derived digestive enzyme preparations were studied. The lipase activity in acetate buffer solution at pH 3.3, 4.0, 5.0, 6.0, where the substrate was olive oil emulsion, was measured by the back titration. The Fe ions used were ferrous sulfate and ferric choride. Test solutions were the mixtures of 5ml of emulsion, 4ml of buffer and 1ml of sample ; they were kept at 37℃ for 30min. Then, the lipase activity with Fe substrate (Fe ion solution 1ml) and that without Fe substrate were compared. As a result, no inhibitory action of Fe ion was showed in each sample. On the other hand, it was found that the action on gastric soluble part of two kinds of digestive enzyme preparations increased remarkably at pH 5.0 and 6.0.
日本医療薬学会の論文
1982-08-20