経口抗生剤の吸収におよぼす服用時の水分量の影響

概要

論文の詳細を見る
In order to evaluate the influence of the volume of water in oral administration upon the absorption of orally administered antibiotics, comparative evaluation was made with AMPC which was found in the previous study to have good absorbability and ABPC having poor absorbability when orally administered. The two antibiotics were given to 4 healthy male volunteers in dose of 500mg. Water was orally given with the antibiotics in two different volumes, 30 and 150ml, in fasting and non-fasting (less than 5-minute postprandial) states, and the blood levels of the antibiotics and their excretion rates in urine were determined by crossover method. It was suggested that AMPC, particularly when administered in fasting, would give smaller individual difference in absorbability if the volume of water was increased. In contrast, no specific effect of the amount of water was exerted upon the absorbability of ABPC given in any state of fasting and non-fasting. When given postprandially, the time required for reaching the peak blood level of both antibiotics was delayed irrespective of the volume of water.
日本医療薬学会の論文
1981-12-20