カラム法による安息香酸錠およびプレドニゾロン錠の溶出試験

概要

論文の詳細を見る
In vitro dissolution test in column-type method or rotating basket method and disintegration test were carried out for slowly dissolving experimental benzoic acid tablets (I) and commercial prednisolone tablets (II). Plain net was tried for prevention of adhesion of tablets on the bottom of the column, but that increased the values. (II) were apt to float in the column. To prevent floating, the tablets were covered with a convex net, and the coefficient of variation values decreased. The dissolution rate of (I) has a correlation with revolution per min. in the rotating basket method and with flow rate in the column-type method. The column-type method enables to record a differential curves of dissolution and is so sensitive as to detect fine differences between tablets. At the same time the method requires long time of experiment and sometimes causes clogging of filter which results in the change in the flow rate of materials.
日本医療薬学会の論文
1976-08-20