サラシ粉を用いた窒素含有医薬品の微量検出法

概要

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Microdetermination of nitrogen-containing pharmaceuticals by means of bleaching powder on the plate of thin-layer chromatograph was studied. In the bleaching powder method, several drops of 2N-HCl are added to 2-3g of bleaching powder. The powder generates chlorine to chlorinate NH radical which is to be detected by iodo-starch reaction. This method, like tert-butyl hypochlorite (TBHC) method, is one of the most "sensitive" ways of determining pharmaceuticals containing NH radical. However, as in the case of TBHC method, the bleaching powder method showed positive reactions to a number of tertiary amines and cyclic tertiary amines. Further, when large amount of sample were used in this method, a color developed in the presence of some quartery ammonium compounds and nitrogen-free pharmaceuticals. This the bleaching powder method, as well as TBHC method, cannot be a specific method for determination of NH radicals. But it may remain useful as simple method of microdermination of nitrogen-containing pharmaceuticals.
日本医療薬学会の論文