Bleomycin 局所療法用製剤の研究

概要

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Local therapy of postoperative cancers with bleomycin was studied. Bleomycin was mixed in various bases, and inserted into the local site with a hemostatic gelatin sponge. In the in vitro and vivo tests, bleomycin in aluminum soap solution (compound of aluminum monostearate and sesame oil) as a base proved most excellent from the viewpoint of local retention, tissue permeability and local hemostatic effect. The preparation produced no undesirable effects on the normal tissue. The therapeutic effect was sustained long. It is, therefore, considered that aluminum soap solution is the base of first choice in the local bleomycin therapy.
日本医療薬学会の論文