消化酵素カプセル剤の酵素活性および溶出性の検討

概要

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Three brands of commercial multiple digestive enzyme capsules (EX, RZ and FT) were tested for their digestive enzyme activities and dissolution of enzymes in the solution of pH 3.0, 5.0, 6.5 and 7.5. Further, digestive enzyme activities and weight variations of the products in three different lot numbers were compared with each other. EX had strong activities of lipase and protease (pH 7.0), but acid-resistance of enteric coated granules was relatively weak. Enzyme activities of RZ and FT were not so strong, but their enteric coated granules showed satisfactory acid-resistance, being dissolved in the solution with pH 6.5 but not in the solution with pH 5.0. Generally, inter-lot differences of enzyme activities were found to be comparatively small.
日本医療薬学会の論文
1978-08-20