熱測定法による市販糖衣錠の崩壊測定

概要

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The thermal analysis was applied to the quality control of tablets at hospital pharmacy. By using of twin type calorimeter with Dewar's vessels, disintegration and dissolution processes of 16 kinds of commercial sugar-coated tablets (11 kinds of single ingredient tablets and 5 of compound tablets) were examined in the acidic test solution. The results were compared with dissolution curves obtained by the UV method and disintegration time according to J. P. VIII. Thermogram showed various disintegration and dissolution patterns, and revealed intro- and interlot variations in the disintegration of tablets and aging effect on the disintegration of tablets. This method also made apparent the difference among disintegration processes which was not detected with dissolution curves and the gap between the disintegration times which could not observed by the disintegration test of J.P.VIII.
日本医療薬学会の論文