NEUTRALIZATION OF TOXOPLASMS WITH SPECIAL REFERENCE TO THEIR INTRA- AND EXTRACELLULAR LOCALIZATION
スポンサーリンク
概要
- 論文の詳細を見る
Neutralization in vitro of toxoplasms was investigated paying special attention to their intra- and extracellular localization. Toxoplasms were obtained from the ascites of infected mice. To detect the neutralization effect, mice were used as experimental animals, the subcutaneous route of inoculation proved to be successful. Inactivated immune rabbit serum neutralized extracellular, but not intracellular toxoplasms. Addition of fresh human serum to the neutralization system decreased the number of intracellular toxoplasms resulting in a considerable acceleration of neutralizing effect. This finding was investigated and the authors found that this was due to the cytolytic action of human serum on mouse ascitic cells containing toxoplasma intracellularly. The lysis of mouse ascitic cells by human serum was proved by microscopic examinations and also by demonstrating the loss of cell nucleotide. It is to be emphasized that toxoplasms could be neutralized by heat stable specific antibody, in accordance with the previous report of YANAGAWA & HIRATO (1963).
- 北海道大学の論文
著者
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IWASAKI Naoko
Department of Medicine, Diabetes Center, Tokyo Women's Medical University
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Iwasaki Naoko
Department Of Medicine Diabetes Center Tokyo Women's Medical University
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YANAGAWA Ryo
Department of Hygiene and Microbiology Faculty of Veterinary Medicine Hokkaido University
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Yanagawa Ryo
Department Of Veterinary Hygiene And Microbiology Faculty Of Veterinary Medicine Hokkaido University
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