1 骨芽細胞様細胞による各種セラミックスの生体適合性評価(第495回大阪歯科学会例会)

概要

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We investigated the effect (in vitro) of ZrO_2, Si_3N_4 and TiN on the activity of the human osteoblast-like cells, Saos-2. The initial cell attachment of ZrO_2 and Si_3N_4, as evaluated by the methylthiazole sulfate test, was greater than that of TiN, which was the same as that of the control. The viability after 72 hr of culture with ZrO_2 was the same as that of the control, but greater than that with Si_3N_4 or TiN. The average ALP, as assayed by the release of p-nitrophenol from p-nitrophenylphosphate, was greater for the three ceramics than for that of the control. Although the collagen type I mRNA expression level was also greater for the three ceramics than for that of the control, only the difference between TiN and the control was significant. The results of this study lead us to conclude that the three ceramics did not disturb cellular activity.
大阪歯科学会の論文
2004-12-25