14 Prevotella intermedia MA1-V2のβ-lactam薬耐性におけるβ-lactamaseの役割(第469回 大阪歯科学会例会)

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概要

• 論文の詳細を見る

• I studied β-lactamase, outer membrane permeability (OMP), and efflux of drugs to elucidate the mechanism of β-lactam antibiotic resistance of Prevotella intermedia MA1-V2.0.25〜8μg / mL of CVA, SBT, and TAZ, and 1 / 16 MIC of PIPC, CEZ, and CFTM were added to cultures at the middle logarithmic phase and the treatment continued for 30 minutes.The β-lactamase activity in the periplasmic space of these cells was inhibited 80〜96%.The percentage varied depending on the β-lactamase inhibitor and β-lactam combination.The inhibitors inhibited β-lactamase activity in the periplasmic space, and decreased the viable count and MIC of 3 β-lactams.I studied the effect of OMP on the MIC of β-lactams, and also measured the viable count with carbonyl cyanide m-chlorophenyl-hydrazone to study efflux of drugs.No decrease was detected in either the MIC or viable count.These results suggest that β-lactamase of this strain play a direct role in the resistance of β-lactam antibiotics.

• 大阪歯科学会の論文
• 2000-03-25

著者

• 前田 健生

  大阪歯大・大学院・口腔外科第1

関連論文

• Prevotella intermedia MA1-V2のβ-lactam薬耐性におけるβ-lactamaseの役割(大阪歯科大学大学院歯学研究科博士(歯学)学位論文内容要旨および論文審査結果要旨の公表)
• 14 Prevotella intermedia MA1-V2のβ-lactam薬耐性におけるβ-lactamaseの役割(第469回 大阪歯科学会例会)
• Prevotella intermedia MA 1-V2のβ-lactam薬耐性におけるβ-lactamaseの役割

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