ダイオキシンの遺伝的影響の問題点 : 継世代的影響について : シンポジウム : II. ダイオキシンの生体影響

概要

論文の詳細を見る
Although a higher risk of congenital malformations has been reported in the children of fathers who had been exposed to dioxin-contaminated herbicides, genotoxicities of the dioxins are unclear in in vitro experimental systems using bacteria and culture cells, and also in the mouse and human germ cells. In the series of experiments co-ordinated by the "Man and Earth" project, however, indirect death of the mouse sperm by the damage to Sertoli cells and significant reduction of fertility and live births were observed. Furthermore, significant increase of functional defects like respiratory distress syndrome was observed in the F* fetuses of TCDD-treated male mice of two different strains. Morphological anormalies were 5 to 8 folds higher than control, although differences were not significant because of small sample size. Increased incidence of molecular changes, i.e., Iength polymorphism of repetitive DNA sequences (pc-3 ) was also detected but it was not statistically significant at present. Large scale experiments are in progress. (This paper, in a session chaired by Taisei Nomura and Kazuo Hujikawa, was presented to the sympo-sium "Biological effects of dioxins", organized by Taisei Nomura, at the 27+" annual meeting of the Environmental Mutagen Society of Japan, and held at the Mielparque Osaka in Osaka, Japan, Novem-ber, 24-26, 1998.)
日本環境変異原学会の論文
1999-07-12