ダイオキシン類の人体汚染の現状 : シンポジウム : II. ダイオキシンの生体影響

概要

論文の詳細を見る
All dioxin analogues composed of polychlorinated dibenzo-p-dioxins (PCDDs) , polychlorinated dibenzofurans (PCDFs) and coplanar PCBs (Co-PCBs) are extremely toxic. Even at the environmental pollution level, there is evidence that they cause hormonal disturbance in women. It has also been pointed out that they can lead to immunosuppression and can alter gonadal functions in humans. Therefore, in recent years, various countries including Japan, U.S.A., Canada and European countries have actively taken measures to decrease environmental pollution levels of these chemicals. Taking the above circumstances into consideration, and from a review of relevant articles published in Japan and elsewhere, this paper outlines the key biological and toxicological issues of this important area. The reports from this laboratory are also included in this review. In addition, risk assessment on recent human exposure to environmental dioxin analogues was carried out using a tolerable daily intake (TDI) approach. This paper also examines the rational for establishing the TDIs in Japan and in other countries. (This paper, in a session chaired by Taisei Nomura and Kazuo Hujikawa, was presented to the symposium "Biological effects of dioxins", organized by Taisei Nomura, at the 27^<th> annual meeting of the Environmental Mutagen Society of Japan, and held at the Mielparque Osaka in Osaka, Japan, November, 24-26, 1998.)
日本環境変異原学会の論文
1999-07-12