茶カテキン類の抗変異原性および抗発がん性(II)

概要

論文の詳細を見る
Recently, the antimutagenic and anticarcinogenic activities of green tea and black tea are extensively examined. The active chemical components of green and black tea are polyphenols, which include EC, ECG, EGC, EGCG and TFs. In the previous paper of the present review, the epidemiological and experimental studies on the antimutagenicity of tea extracts and tea polyphenols have been described (Kuroda and Hara, 1999b). In the present article, the experimental studies on the anticarcinogenicity of tea extracts and tea polyphenols are described. The anticarcinogenic activity of tea polyphenols has been shown in experimental animals such as rats and mice, and against lung cancers, skin tumors, leukemia, tumor promotion and metastasis. The mechanisms of antimutagenesis and anticarcinogenesis of tea polyphenols suggest that the inhibition of tumors may be due to both extracellular and intracellular mechanisms including the modulation of carcinogen metabolism, of DNA replication and repair, and of tumor promotion, the inhibition of metastasis, and the induction of novel mechanisms. This article is a Japanese edition of the review article published in Mutation Research, (Kuroda and Hara, 1998) with the permission of Elsevier Science Publishers B. V.
日本環境変異原学会の論文
1999-07-12