モノクロナール抗体を用いたベーチェット病患者末梢血リンパ球サブセットの検討

概要

論文の詳細を見る
To define the pathogenesis of Behcet's disease, peripheral blood lymphocyte subsets (OK T4, OKT8, OKIa1) and E rosette formation from 21 patients with Behcet's disease and 11 healthy controls were examined. Following observations were made. 1. In Behcet's disease, there was no difference between Behcet's disease and healthy controls in percentage of E rosette forming cells. 2. In Behcet's disease, a ratio of OKT4^+ cells and OKT4^+ /OKT8^+ were significantly lower than controls (p<0.02). (p<0.02). 3. In Behcet's disease, percentage of OKT8^+ cells and OKIal^+ cells were significantly higher than controls (p<0.02, p<0.01). 4. In the active stage of Behcet's disease, percentage of OKT4^+ cells were lower, percentage of OKT8^+ were higher than those in inactive stage of Behcet's disease. 5. In Behcet's disease, percentage of Ia+T cells were significantly higher than controls (p< 0.01). 6. In the active stage of Behcet's disease, percentage of Ia^+T cells were higher than that in inactive stage of Behcet's disease (p<0.05). 7. These findings suggested that proportionally umbalance T cell subsets existed in patients with Behcet's disease. One speculation is proposed that abnormalities of cellular imununities were related to the etiology and clinical course of Behcet's disease.