クエン酸第一鉄ナトリウム改良顆粒剤の配合試験

概要

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Sodium Ferrous Citrate formulation. Ferromia^<[O!R]> granule was originally supplied as film-coated granules. However, some problems have been pointed out with this formulation regarding awkwardness in handling and unpleasantness during consumption. Therefore, corrigent was added while the film conting was removed in order to improve it. We investigated influence of changing the formilative method,and carry out the incompatibility test and hygroscopic test on 29 powders which can be admixed together. Furthermore, we also carried out a ferrous ion dissolution test on I I powders which are likely to have an ionic interaction with lron. As a result, the modified granuls were incompatible when combined with ascorbic acid powder. Cinal^<[O!R]> granule, sodium bicarbonate and folic acid powder (10%). The modified granules demonstrated no water-vapor sorption at 25℃, 75% RH at 30 days. Hygroscopicity was not considered to be related to incompatibility, and no noticeable difference was found due to the modification of the formulation. In the compounding the sample, dissolution property demonstrated only a slight difference in the ferrous ion elution.
日本医療薬学会の論文
1999-04-10