α-TCP処理による生体材料の組織適合性

概要

論文の詳細を見る
Titanium coated with α-TCP was prepared by plasma spraing β-TCP powders on titanium. The α-TCP coating was examined crystal-chemically by the X-ray diffraction method. Moreover, the biocompatibility of α-TCP was examined by animal experiment. Solubility and tissue reaction of α-tricalcium phosphate(α-TCP) plasma-coated layers on titanium were examined by subcutaneous implantation tests. The α-TCP plasma-coated layers were prepared by plasma spraying of β-TCP powder on titanium. Hydroxyapatite (HAp) plasma-coated layers on titanium were used as controls. An in vivo solubility test was carried out as follows: Thirty six samples of (10×10×1 mm) were implated in subcutaneous tissue of a mongrel dog's back. At 1, 2, and 3 months after implantation, the coated layers were investigated by X-ray diffractometry (XRD) and SEM observation, weight-loss measurement, and histological estimation. The transformation of the surface of the α-TCP coated layers into HAp was detected by the XRD more than 1 month after implantation. Weight loss of the α-TCP coated layers 2 months after implantation was 1.5 times greater than that of the HAp coated layers, and at 3 months, 1.6 times greater than that of the HAp coated samples. Slight inflammatory reaction was observed in the connective tissue on the α-TCP coated layers as well as on the HAp coated layers.
硬組織再生生物学会の論文
1994-03-25