うつ病に対するHF-1927/Noverilの二重盲検比較実験

概要

論文の詳細を見る
Noveril (Dibenzepine) has a new structure and has ethyl-amino-group as a side chain, which is never seen in any other neuroleptics until now.It was tried to investigate the effect of Noveril through the double blind trial using Amitriptyline as a standard drug.Twenty matched pairs were observed for eight weeks and the progress was registered on a rating scale. The result obtained was analysed through the sequential analysis, chi square test and t-test.As the result, any significant differences between the effect of Noveril and that of the standard drug were not recognized in any respects of the general improvement of depression, influences on diagnosis, target symptom pattern, etc.As to the side effects, while Amitriptyline caused such complaints of "sleepy in day-time" and "mouth dryness", Noveril caused chiefly "tight freeling" and "irritation". That is to say, Amitriptyline brings the side-effect of "sleepy in day-time", but has rather strong sedative and hypnotic effect against "anxiety" and "agitation".Consequently, in point of effect, Noveril can be said to be an in-between drug of Imipramine and Amitriptyline.
日本心身医学会の論文
1971-08-01