ELECTRON MICROSCOPIC OBSERVATIONS ON THE MONONUCLEAR CELLS IN THE PERIPHERAL BLOOD OF THE CLINICALLY NORMAL AND LYMPHOSARCOMA COWS

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The mononuclear cells obtained from the peripheral blood of the two groups of clinically normal and pre-leukemic lymphosarcoma cows were examined with the use of an electron microscope, and the findings were discussed comparatively. The results thus obtained were summarized as follows. 1) In the peripheral blood of the clinically normal and lymphosarcoma cows, there were lymphocytes, monocytes, plasmacytes and 4 other types of mononuclear cells which were classified temporarily by the authors into plasmacytic, monocytic, small lymphocytic and large lymphocytic mononuclear cells. The large lymphocytic mononuclear cells were observed more frequently in the blood of the lymphosarcoma group. 2) In the lymphocytes of the clinically normal group, the cells with nuclear inclusion bodies were sometimes observed and the cells with nucleoli and well-developed Golgi complex were observed rarely. The cells with nuclear invaginations and nuclear defects were not observed at all. 3) In the lymphocytes of the lymphosarcoma group, the cells with nucleoli, nuclear invaginations, nuclear defects and well-developed Golgi complex were sometimes observed, but the cells with nuclear inclusion bodies were observed very rarely. 4) There were no significant differences in the frequency of appearance of these mononuclear cells excepting large lymphocytic mononuclear cells between clinically normal and lymphosarcoma groups. 5) Virus-like particles were observed in the content of a nuclear defect of the lymphocyte in one case of the lymphosarcoma group.
北海道大学の論文

ELECTRON MICROSCOPIC OBSERVATIONS ON THE MONONUCLEAR CELLS IN THE PERIPHERAL BLOOD OF THE CLINICALLY NORMAL AND LYMPHOSARCOMA COWS

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