Superantigenic exotoxin production by isolates of Staphylococcus aureus from the Kawasaki syndrome patients and age-matched control children
スポンサーリンク
概要
- 論文の詳細を見る
Nineteen strains of Staphylococcus aureus were isolated from the throat or the tooth surfaces of 19 cases amongst 127 patients with Kawasaki syndrome (KS) during the acute phases and 11 S. aureus isolates were obtained from five of 17 diseased controls and six healthy controls. The production of exotoxins, particularly superantigenic toxic shock syndrome toxin-1 (TSST-1), coagulase serotype, pigment production, haemolytic activity and tryptophan auxotrophy of these isolates were compared. Among 10 KS S. aureus strains isolated in 1990-1991,five (50%) secreted TSST-1,a higher frequency than two (18%) of 11 control isolates. In contrast, none of the nine KS strains collected in 1984 produced TSST-1. Four of five TSST-1-secreting KS strains produced white or white to golden pigmentation, whereas the two control strains capable of TSST-1 production formed golden colonies. There were no noticeable differences between S. aureus strains from KS patients and control children in the production of staphylococcal exotoxins A-E, coagulase serotype, haemolysis of sheep erythrocytes and tryptophan auxotrophy. The pathological or aetiological role of a new TSST-1-secreting S. aureus clone in patients with KS was not confirmed.
- 日本医科大学の論文
- 1995-03-25
著者
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HARADA K.
Department of Physics, Osaka University
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Ohkuni H.
Division Of Immunology Institute Of Gerontology Nippon Medical School
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IGARASHI H.
Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
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KOTANI S.
Osaka College of Medical Technology
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TODOME Y.
Division of Immunology, Institute of Gerontology, Nippon Medical School
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MIZUSE M.
Division of Immunology, Institute of Gerontology, Nippon Medical School
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OKIBAYASHI F.
Division of Immunology, Institute of Gerontology, Nippon Medical School
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OHTANI N.
Division of Immunology, Institute of Gerontology, Nippon Medical School
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SUZUKI H.
Division of Immunology, Institute of Gerontology, Nippon Medical School
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SONG C.
Division of Immunology, Institute of Gerontology, Nippon Medical School
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SAKURAI S.
Division of Molecular Genetics, Jikei University School of Medicine
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Okibayashi F.
Division Of Immunology Institute Of Gerontology Nippon Medical School
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Mizuse M.
Division Of Immunology Institute Of Gerontology Nippon Medical School
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Todome Y.
Division Of Immunology Institute Of Gerontology Nippon Medical School
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