インターロイキン-15による生体防御調節機構
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概要
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Although some functional effects of interleukin (IL)-15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice lacking components of the IL-2/IL-15 system demonstrate distinct roles of IL-15 in activation of the innate as well as acquired immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, and TCRγδ^+ intestinal intraepithelial lymphocytes and plays an inportant role in functional maturation of dendritic cells and macrophages. IL-15 is also involved in memory T cell maintenance in vivo. In this review, I summarize recent progress made in studies of the IL-15/IL-15R system.innate immunityacquired immunitydendritic cellimmunological memoryhomeostatic proliferation
- 東北大学の論文
- 2002-12-27