<特別寄稿>インターロイキン-15による生体防御調節機構
スポンサーリンク
概要
- 論文の詳細を見る
Although some functional activities of interleukin (IL) -15 on NK and Tcells overlap with those of IL-2, recent findings obtained from gene-targeted micedeficient in components of IL-2/IL-15 system demonstrate distinct roles of IL-15 for theactivation of innate as well as acquired immune system. IL-15 is a pivotal cytokine forthe development and survival of NK cells, NKT cells, TCRyu+ intestinal intraepitheliallymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages.IL-15 is also important for memory T cell maintenance in vivo. In this review,I summarize recent progress of studies in the IL-15/IL-15R system.
- 秋田大学の論文