レーザーの骨再生促進効果のメカニズム : 骨形成因子による骨誘導系からのアプローチ

概要

論文の詳細を見る
This experiment was designed to approach the mechanism for the bone regeneration effect of lasers through the bone induction using a bone inductive substance 'BMP' (bone morphogenetic protain). The collagen based BMP pellet of a constant BMP content was implanted into the subcutaneous region of the back skin of a mouse. In the lased group the BMP implanted wound was exposed to the laser beam of low power lasers. The GaAlAs laser and the He-Ne laser of mW level of output power were applied in this experiment. The bone formation induced by the BMP pellet in the lased group was compared to that of unlased group (control). As a result, the lased groups were superior to the unlased group not only in quantity but also in mineral contents of the induced bone. The result of this study proposes one of a new mechanism for bone regeneration effect of lasers as follows : Lasers activate the BMP bone induction system to lead the activation of the bone regeneration. From the result of this experiment alone, however, it cannot be documented whether the lasers stimulate the host tissue to activate the postfetal cytodifferentiation of the undifferentiated mesenchymal cells induced by BMP into osteoblasts or the lasers stimulate the activity of BMP in the basal bone matrix.
東海大学の論文
1998-03-30