サリチル酸中毒に関する研究(第II報) : サリチル酸長期投与ラットの病理学的研究

概要

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Intoxication of salicylic acid was experimented on Wister rats. The salicylic acid that dissolved in drinking water was administered to rats for 98 weeks. The experimental groups were administered each of salicylic acid solution in 0.025% (1st group), 0.1% (2nd group), 0.2% (3rd group). Part I (Takagi et al, 1973) reported on hematological, serological and biochemical approaches to this problem. The present paper is concerned with the gross anatomical and histopathological examination. Gross anatomically in lungs of half of the rats lesion by neoplasma was observed but no remarkable chenges in other organs. Histopathological examinations were as follows. ln most livers of the rats increased kuppffer's cells, Inlarged sinusoid, affected nucleus in liver cells were seen. Half of the rats showed slight lipoid metamorphosis in spongiocytes of adrenal glands and some chenges in other organs.
岐阜聖徳学園大学の論文