<Originals>Atrophy of spinal cord in groggy mutant rat

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概要

• 論文の詳細を見る

• The groggy rat is a single autosomal recessive mutant with a movement disorder, whose onset is about 15 days of age. The cerebellum, medulla oblongata and spinal cord of adult groggy rat are slightly atrophied. The present histological examinations of the spinal cord revealed that in the 360-day-old groggy rat, atrophy was restricted to white matter, whereas the transverse-sectional area of gray matter was not different from age-matched Slc : Wistar rat. The number of motor neurons in the lumber spinal cord did not differ between two rat groups. During postnatal growth of the spinal cord, a reduction in the transversesectional area of the whole spinal cord occurred in the groggy rat from 20 days of age onward. Light and electron microscopic studies revealed numerous degenerative myelinated axons in the dorsolateral funiculus of the spinal cord of 30-day-old groggy rat, but no discernible abnormalities were observed in the dorsal root. These findings suggest that the groggy rat may be an animal model of human autosomal recessive spinocerebellar degeneration.

• 岐阜医療科学大学の論文
• 2001-12-30

著者

• Takeuchi Yoshiko

  College Of Medical Technology

• Takeuchi Ikuo

  Institute For Developmental Research Aichi Human Service Center

関連論文

• Neuronal degeneration in the septum of groggy mutant rat
• BASIC PROTEINS IN THE NUAGE OF GROWING CHINESE HAMSTER OOCYTES
• Age-related Appearance of Dystrophic Axon Terminals in Cerebellar and Vestibular Nuclei of Mongolian Gerbils
• ELECTRON MICROSCOPY OF THE EFFECTS OF 5-AZACYTIDINE, 50 R X-iRRADIATION, AND VINBLASTINE ON THE TELENCEPHALIC WALL OF THE RAT FETUS (The Fourth Meeting for the Study of Toxic Effect)
• Atrophy of spinal cord in groggy mutant rat
• Synaptophysin Accumulation in Axonal Swellings Occurring in the Cerebellar White Matter of Groggy Mutant Rats
• Ubiquitin Immunostaining of Axonal Swellings in Lateral Cerebellar Nuclei of Groggy Mutant Rat

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