脊髄における疼痛情報伝達と鎮痛機構

概要

論文の詳細を見る
The goal of pain research and clinical practice is the relief of unnecessary suffering. The first-order link of the pathway through which information generated by a nociceptive stimulus is projected to higher centers occurs at the spinal cord level. The spinal cord has served as an important base for investigations into function at the neuronal and systems level. The complex pharmacology of systems that modulate sensory processing within the spinal cord holds great promise for improved ways of providing spinal analgesia. High selectivity of analgesic drugs may be one of the most appealing strategies for the near term improvement of pain management. By using combinations of drugs targeted on different receptors and cellular mechanisms, one can, in theory, reduce dose-related side effects while maintaining a greater level of pain relief. Our knowledge of the basic mechanisms of pain sensation and analgesic drug action is in a phase of rapid growth and there are a variety of promising new analgesics at various stage of development.
札幌医科大学の論文
2001-12-01