<原著>卵巣摘出術がラットの切歯の横断面形態に及ぼす影響

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Rat incisors grow continuously throughout life, indicating that bone and mineral metabolic changes may be reflected in the morphology of rat incisors. However, the effects of ovariectomy (OVX) on rat incisal morphology are uncertain. The present study examined the effects of OVX on the morphology of the cross sections of rat incisors. Twenty four of six-month-old female Wistar rats, divided into four weight-matched groups, each with six animals, were either ovariectomized or sham-operated and maintained until sacrifice. The effects of OVX on the body weight, weight of organs including the uterus, bone mineral density of the tibias, tooth mineral density of the lower incisors and histology of the lower incisors on the cross sections were examined 10 and 26 weeks after the surgery. The results were as follows; 1. The treatment of OVX significantly increased the body weight and decreased the weight of the uterus and the bone mineral density of the tibias at 10 and 26 weeks after the surgery. 2. While OVX failed to significantly affect the tooth mineral density of the lower incisors, the formation rate of dentin and the total area of tooth, it significantly increased the thickness of dentin and markedly decreased the area of the pulp in the cross section. 3. The treatment of OVX did not markedly affect the morphology of ameloblasts, odonto-blasts, and cells in pulp. These results indicate that the decreased area of incisal dental pulp induced by OVX could be a landmark for OVX in rats, as well as the decreased uterine weight and the bone mineral density or the increase in body weight.
北海道医療大学の論文
2001-06-30

<原著>卵巣摘出術がラットの切歯の横断面形態に及ぼす影響

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