<原著>Actinobacillus actinomycetemcomitansにより惹起されるマクロファージ細胞死のメカニズムの解析 : アポトーシスによる細胞死の可能性について

概要

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The gram-negative periodontopathic bacteria Actinobacillus actinomycetemcomitans causes juvenile periodontitis. In the present study, A. actinomycetemcomitans was shown to be cytotoxic to J774A.1 cells, a monocyte-macrophage cell line, and to murine alveolar macrophages. All five strains of A. actinomycetemcomitans were able to induce cell death, whereas two strains of Porphyromonas gingivalis, the causative agents of adult periodontitis, were not toxic. We demonstrated that cell cytotoxicity mediated by A. actinomycetemcomitans Y4 occurred through apoptosis, as shown by changes in nuclear morphology and by an increase in the proportion of fragmented DNA of J774A.1 cells. We sought to determine whether cytotoxicity mediated by A. actinomycetemcomitans Y4 could be modulated by inhibitors of protein kinase. Apoptosis mediated by A. actinomycetemcomitans Y4 was suppressed by inhibitors of protein kinase C.
北海道医療大学の論文
1995-06-30