<原著>試作シアノアクリレート系裏製材の細胞毒性 : ミリポアフィルター重層法による細胞毒性評価

概要

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In a previous study (J.Jpn.Prosthodont.Soc. ,33:1388-1397, 1989.), Ochi et al., reported on the adhesive strength of cyanoacrylate dental cement (F.H cement^[○!R]), and showed that even after thermal-cycle treatment the cement had an adhesive strength to dentin which was nearly equal to that of the dental adhesive resin (Panavia EX^[○!R]) under the same treatment conditions. Nakagawa et al. investigated the pathology of dental pulp treated with F.H cement^[○!R] and reported that the cement had a protective effect. Based on these previous reports we produced an experimental cyanoacrylate base cement. In this experimental base cement, the liquid compound was to isobutyle-cyanoacrylate instead of the ethyl-cyanoacrylate used in F.H cement^[○!R]. The purpose of the study reported here was to use the millipore filter method to evaluate the cytotoxicity of the experimental base cement on herdening process of the cement, from mixing it complete hardening. The filters were examined macroscopically and scores from 0 to 3 were assigned to grade the severity of the cell respons. The experimental base cement showed no toxic effect on the cells even immediately after mixing. It was concluded that the experimental base cement was the least toxic compound in its effect on the cells. Accordingly, the experimental base cement is harmless to dental pulp in clinical uses in dentistry.
1992-12-31