Food Intake and Induction of Primary Moloney Sarcoma Virus-induced Tumors in Mice

概要

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Mice fed ad libitum were tested for 4 days after their inoculation at 30∿32 days of age. The rate of tumor induction by Moloney Sarcoma Virus (extract diluted at 1/7×10^<-3>) was about 40 percent. Urinary substances from all inoculated mice were estimated every day. Food Intake and Body Weight were measured every four days for their less amount. Body Weight gain/day to Food Intake/day was 0.52g to 3.50g in Induction (I) group and 0.53g to 3.03g in No Induction (N) group. Creatinine/M. B. W. and Uric acid/M. B. W. showed no differences between I group and N group and between Males and Females. In Intake/M. B. W. a significant difference was found between I group and N group. Each urinary substance divided by Food Intake represented the metabolic state in both groups. Creatinine/Intake showed that excretion of creatinine didn't vary with Food Intake, and has a significant difference between I and N group. Uric acid/Intake showed that excretion of uric acid had a difference between Males and Females. Urea-N/Intake and Amino acid/Intake presented that both excretion of Urea-N and Amino acid increased with the Food Intake, and had no difference between I group and N group. The mice inducing tumor seem to have a higher metabolic activity of caloric foodstuffs.
金城学院大学の論文
1977-12-25