The Two of Urinary Allantoin and Urea-N and Induction of Primary Moloney Sarcoma Virus-induced Tumors in Mice
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概要
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To learn a relationship between urinary substances and tumor induction by virus in mice, the exretion rate of allantoin, urea, P, Mg from mice inoculated with virus and their food intake and growth were determined. Female BALB/C mice were started to be fed the diet containing only casein (25%) as the protein source at 30-32 days old and inoculated with Moloney Sarcoma Virus (MSV) extract 1/2×10^<-2> at 51-53 days of age. The MSV extract was obtained from the tumors by the virus allowed to stand at room temparature 20° for six days. All tumors induced 9/22 progressed and killed the animals in tumor induction group (I-group). No tumor inductions were seen for 31 days after inoculation in tumor no induction group (Ni-group). Collecting 3 days urine for 15 days from mouse in each metabolic cage was started at 40-42 days old and completed 3 days previous to the first tumor induction. Growth, food intake and four urinary substances did not differ significantly between I-group and Ni-group. Food intake increased slightly through the experiment. On the contrary, urinary exretion of allantoin, P and Mg decreased gradually in both groups. Allantoin (A)/ureu-N(U) in I group was significantly bigger than that in Ni-group (P<0.05). While the mice placed in the same environment take the same diet through the test, urinary excretion of urea from them is always constant. The value A/U, therefore, represents the sequences of their native activities of purine nucleotides metabolism.
- 金城学院大学の論文
- 1979-02-10
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関連論文
- Induction and Growth of Primary Moloney Sarcoma Virus-induced Tumors in Mice
- The Two of Urinary Allantoin and Urea-N and Induction of Primary Moloney Sarcoma Virus-induced Tumors in Mice
- Food Intake and Induction of Primary Moloney Sarcoma Virus-induced Tumors in Mice