<原著>ネコにおける脊髄cordotomyの下行性および上行性線維に対する影響

概要

論文の詳細を見る
How the descending and ascending fibers were affected by cordotomy lesion was studied experimentally by the examination of retrogradely labeled cells by retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) in 9 cats. WGA-HRP was injected into the anterolateral funiculus of the upper cervical cord (C2-3) in 7 cats and of the midthoracic cord (T8) in 2 cats. Labeled cells were constantly found in the nucleus of the solitary tract, reticular formation, raphe nucleus, nucleus of the locus coeruleus, parabrachial nucleus, Kolliker-Fuse nucleus, lateral hypothalamic area and posterior hypothalamic area. In addition, some cases showed labeled cells in the retroambigual nucleus, lateral reticular nucleus, cuneiform nucleus, Edinger-Westphal nucleus and medial hypothalamus. These labeled regions have so far been regarded as respiratory-, micturition- and pain modulation-related areas. Labeled cells in the cervical and lumber enlargements were observed in lamina I, IV, V, VI, VII, VIII, X. But no labeled cell was found in lamina I in the cases which WGA-HRP injection didn't extended to the dorsolateral funiculus. These observations explain why the cordotomy lesion may induce disturbances in breathing and micturition without proper section of the spinothalamic tract, and recurrence of pain.
近畿大学の論文
1993-12-25