<原著>気管支喘息における肺弾性と末梢気道閉塞
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effects of lung elasticity on the airway in asthma by analyzing the relationship between decreased elastic lung recoil and peripheral airway obstruction in 55 patients with asthma. Factors affecting the severity and intractability of asthma are also discussed. Spirometry was performed, and functional residual capacity (FRC) was determined using the He dilution method. Respiratory impedance (Zrs) was measured by the oscillation method (3Hz). A single N_2 washout curve was obtained to determine closing volume and ⊿N_2/l and volume of isoflow (Visov^^・) and ⊿V^^・_<50> were determined from Air and He-O_2 flow volume (F-V) curves. On the basis of the magnitudes of abnormality of these four parameters, the severity of peripheral airway obstruction was determined for evaluation and used to calculate small airway obstruction (SAO) score, an index of peripheral airway obstruction. Using a Body plethysmograph, spirometry was then performed, and F-V curve, airway resistance and thoracic gas volume were determined. Static pressure-volume curve was obtained using the esophageal balloon method to determine static lung recoil pressure [Pst(1)] at 80% total lung capacity (TLC), specific lung compliance [Cst(1)/FRC], and dynamic compliance. In twenty patients, lung elasticity was measured before and after inhalation of the β_2-stimulant orciprenaline. Changes in lung elasticity and other parameters were analyzed to examine their effect on airway obstruction. The relationships of pulmonary function parameters to severity and type of asthma, dependence on oral steroids, and smoking were examined. 1) There was marked correlation between decrease in elastic lung recoil and severity of peripheral airway obstruction. 2) Elastic lung recoil was markedly decreased in severe asthma. 3) Marked peripheral airway obstruction was observed in severe asthma. 4) There was no significant difference between patients with severe asthma who were dependent on oral steroids and those who were not in severity of peripheral airway obstruction or in decrease in lung elasticity. 5) The effect on lung elasticity of orciprenaline inhalation was not correlated with severity of airway obstruction, and increased Cst(1)/FRC and decreased Pst(1) at 80%TLC were observed. These results suggest that the process by which bronchial asthma become severe or refractory is deeply related to decreasing in lung elasticity.
- 近畿大学の論文
- 1991-09-25
著者
関連論文
- 10.サルモネラ胃腸炎により溶血性尿毒症を呈して, 初めて診断された遺伝性球状赤血球症の1例
- 23.食道出血によって偶然発見された食道癌と肝細胞癌の同時性重複癌の1症例
- 1.治療に難渋した気管支喘息の1例
- 19 気管支肺洗滌の被検者に及ぼす影響(第 3 報)(気管支・洗浄 (2))
- 117 気管支喘息におけるprostaglndinsの気道反応におよぼす影響(第4報) : アセチルコリンならびにプロスタグランディン吸入試験の比較検討(気管支喘息:病態生理3)
- モルモットにおけるin vivo肺圧量曲線におよぼす人工換気の影響
- 10. 気管支鏡下肺胞洗浄により軽快した肺胞蛋白症の 1 例(第 47 回日本気管支学会近畿支部会)
- 150. 在宅酸素療法患者のQOLに及ぼす背景因子について(QOL)
- 気管支喘息患者における occlusion pressure 法による気道過敏性の検討(気道過敏性と気管支学的諸問題)
- 気道出血に対するフィブリノゲン, トロンビン局所注入の止血効果に対する検討(気道出血)
- 15.気管支喘息における気管支拡張剤吸入による末梢気道閉塞と肺弾性との関係
- 呼吸器疾患を中心とした入退院時の各種心理テスト成績 (第5報) : 第8回日本心身医学会近畿地方会演題抄録
- 16.ネコ摘出肺におけるPAF気道内および血流内投与の肺微小循環および気道におよぼす影響
- ネコ摘出還流肺におけるメサコリン, ヒスタミン気管内投与の効果
- 12 薬剤の影響からみたOA感作による2相性反応モデルの検討(第2報)
- 425 Cis-platinumを主体とした多剤併用療法による非小細肺癌の治療成績
- 気管支喘息における肺弾性と末梢気道閉塞
- 306.気管支喘息の各タイプ別にみた気道過敏性と気道狭窄部位との関係について(気管支喘息:肺機能)
- 269.気管支喘息におけるprostaglandingsの気道反応におよぼす影響(第5報) : アセチルコリン, メサコリンおよびプロスタグランディンF_吸入試験の比較検討(Chemical mediator II)
- 34.実験的喘息 : モルモットにおける二相性反応モデル
- 33.ネコ肺還流におけるヒスタミン, メサコリン気管内投与の効果
- 27.当科における慢性呼吸不全 : 特に在宅酸素療法について
- 83 気管支喘息における肺弾性の変化と末梢気道狭窄(気管支喘息)
- 82 気道反応の局在性からみた気管支喘息(気管支喘息)
- α・β受容体遮断薬Dilevalolのモルモット気道過敏性におよぼす影響
- タイトル無し