<原著>シスプラチン・リピオドールの経肝動脈および経門脈併用投与によるラット肝癌への影響
スポンサーリンク
概要
- 論文の詳細を見る
To develop a new treatment for hepatic carcinoma, cisplatin (cis-diamminedichloroplatinum II, CDDP), suspended in an oily contrast medium, Lipiodol (LPD), was administered via both the hepatic artery and the portal vein, as well via the hepatic artery alone, into rats with 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB)-induced hepatic carcinoma. Based upon the results of a preliminary experiment using normal rats, the volume was set at 0.1 ml per blood vessel (10 mg of fine ground CDDP suspended in 1 ml of LPD). Prior to the start of the experiment, contrast medium was injected via the hepatic artery or the portal vein into rats with 3'-Me-DAB-induced hepatic carcinoma. Low kilovoltage radiography and tetraline cleared specimens showed that the contrast medium sent through the hepatic artery accumulated selectively in the central area of the tumor nests, while that sent through the portal vein accumulated selectively in the peripheral area. Tumor growth rates in the hepatic artery plus portal vein group (H+P group), compared to the hepatic artery group (H group), were lower 5 days after administration and tended to be even lower on the 21st day. Platinum concentrations in the liver were significantly higher in the carcinoma nests than in the other non-tumorous areas. In the H+P group carcinoma nests, the platinum concentrations were higher than in the H group carcinoma nests. Histologically, carcinoma cells in the peripheral areas of the carcinoma nest, as well as those in the central areas, were moderately degenerated and necrotic. Tumor-disappearing rates (necrosis rates+fibrotic rates) in the H+P group were 65.2% on the 5th day after administration and 69.6% on the 21st day. Both values were significantly higher than those in the H group. Necrosis and degeneration were not found in the non-tumorous areas of the liver 21 days after administration. Body weight in the H+P group, as well as the H group, decreased 5 days following administration, but some of the animals had recovered to their original weight by the 21st day. These results indicate that this new method of combining hepatic arterial plus portal venous administration of CDDP+LPD suspension is very effective in the treatment of hepatic carcinoma.
- 近畿大学の論文
- 1991-06-25
著者
関連論文
- 当院における動脈塞栓療法を中心とした肝細胞癌治療の成績
- 超常磁性体酸化鉄粒子造影剤投与後3D-MRAによる肝癌・門脈・肝静脈同時描出法
- 26.MR cholangio-pancreatography(MRCP)の有用性
- 7.閉塞性動脈硬化症に対するアテロトラックを用いたPTA
- 10.経頸静脈的肝内門脈静脈吻合術(TIPS)施行の2症例
- 3.リンパ浮腫のMRI
- 肝前門脈閉塞症における血管造影の所見 : 発生機序の異なった3例について
- 21.総胆管巨大結石に対する経皮経肝的砕石除去術 : フレキシブル砕石鉗子法の開発と有用性
- 2.3D-CT portographyによる胃静脈瘤治療後の評価
- 8.超常磁性体酸化鉄を用いた3D-MR Angiography : 肝腫瘍と脈管系の同時描出
- シスプラチン脂溶性誘導体の経肝動脈投与によるラット肝癌への影響
- シスプラチン・リピオドールの経肝動脈および経門脈併用投与によるラット肝癌への影響
- 31P-MRS and histological changes of rat liver after intrahepatic arterial injection of lipiodol.