<原著>骨髄移植とコラーゲン関節炎マウスにおける抑制効果

概要

論文の詳細を見る
We examined the effects of bone marrow transplantation (BMT) on type II collagen induced arthritis (CIA) in DBA/1J mice ( H-2^d haplotype). Either before or after the onset of arthritis, the mice were lethally irradiated, then reconstituted with bone marrow cells from normal syngenic (DBA/1J) or allogenic (BALB/c : H-2^d) mice. In the mice treated with BMT before the onset, the appearance of arthritis was either prevented or suppressed. Arthritis was suppressed by BMT after the onset and the anti-type II collagen antibody decreased after BMT. By measurement of the level of intracellular cAMP stimulated with histamine, the function of histamine H2 receptor in lymphocytes and bone marrow cells which were reduced in CIA was recovered after BMT. These effects of BMT were observed more clearly in the allogenic BMT than in the syngenic BMT. The possibility that BMT, in particular allogenic BMT, has preventive and therapeutic effects on CIA warrants further study.
近畿大学の論文
1991-03-25