<原著>新しい除痛法としての後根進入部破壊術 : ネコ・サルを用いた痛覚中枢内伝導路線維結合の追跡
スポンサーリンク
概要
- 論文の詳細を見る
The main pain pathway and fiber connections were anatomically traced out by a series of experiments of dorsal root entry zone lesion (DREZ-lesion) in 21 cats and 2 monkeys (Macaca fascicularis). The ascending projection systems affected by DREZ-lesion were anatomically traced with the aid of Fink-Heimer's degeneration method. Multiple radiofrequency coagulations were made in the dorsal horn of cervical cord of 8 cats and 2 monkeys. The extent of lesions both into the white and the gray matter was estimated in each case. The size and shape of the lesions made within the dorsal horn dependent not only upon coagulation power, but also upon partial damages of cord's superficial vessels. The degenerate axons and terminals in the spinal gray matter were usually observed on the segments from one to four above and below the lesions. These degenerations were seen both in the primary afferent fibers and propriospinal fibers. The terminal degeneration was observed in the lateral cervical nucleus, and the medullary and pontine reticular formation. Furthermore, some degenerate terminals were found in caudal part of the contralateral ventroposterolateral nucleus in monkeys. The descending fiber systems affected by DREZ-lesion were pursued by the retrograde labeling method of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) : WGA-HRP was injected in the cervical dorsal horn of 11 cats, and the retrogradely labeled neurons in the brain stem were observed. The labeled cells were found constantly in the raphe nucleus, magnocellular tegmental field, parabrachial nucleus, coeruleus nucleus, Kolliker-Fuse nucleus and Edinger-Westphal nucleus. These results show that DREZ-lesion can affect the main pain pathway, namely the spinothalamic fibers, and moreover interrupt the spino-cervico-(thalamic) fibers, spinoreticular fibers and propriospinal fibers that have been proposed as accessory pain pathways. Thus, it is suggested which DREZ-lesion offers a selective segmental analgesic effect by shutting off ascending pain signals in the spinal cord. On the other hand, DREZ-lesion would cut off some descending fiber systems as regards the intrinsic pain modulating systems.
- 近畿大学の論文
- 1988-09-25
著者
関連論文
- 22.脳神経外科における脳卒中救急体制の取り組み
- 8. 脳内出血に対する新しい治療法 : 神経内視鏡を用いた低侵襲な治療法
- 3.海綿静脈洞進展腫瘍に対する拡大経蝶形骨洞法(MS-7 下垂体腺腫:手術の基本手技,モーニングセミナー,第26回 日本脳神経外科コングレス総会)
- 内視鏡支援顕微鏡手術(LS-8 脳神経外科領域における内視鏡手術, 第25回 日本脳神経外科コングレス総会)
- 経蝶形骨洞手術の適応と限界 : 内視鏡単独から拡大手術まで
- 3. 頭蓋底腫瘍に対する内視鏡支援(L2-B 内視鏡手術の基本と応用)
- 2.経蝶形骨洞手術への内視鏡の応用
- 経蝶形骨手術における3D-CT画像を用いた手術シミュレーション
- 頭蓋咽頭腫に対する内視鏡支援拡大経蝶形骨手術
- 下垂体腫瘍に対する内視鏡支援拡大経蝶形骨手術
- グラフ 下垂体腫瘍の内視鏡支援手術
- 2.経蝶形骨洞の立場から
- 視神経圧迫および減圧術による視機能変動の電気生理学的評価法
- 20.非典型的CT像を示したLarge Aneurysm
- 13.脳幹損傷呼吸麻痺患者に対する横隔神経刺激による呼吸調節の1経験
- 12.第III脳室内腫瘍の1症例
- 新しい除痛法としての後根進入部破壊術 : ネコ・サルを用いた痛覚中枢内伝導路線維結合の追跡
- CT所見を中心にしてみた脳膿瘍の臨床経過
- 9.虚血性脳血管障害および脳動脈瘤に対するSTA-MCA anastomosis
- 8.脳血管障害における^I-IMPを用いたSPECTの有用性についての検討
- 頚動脈-海綿静脈洞瘻の臨床経験
- 26.両鼻側半盲を呈したprimary empty sella syndromeの1例
- 21.くも膜嚢腫を伴った小脳橋角部類上皮腫の1例
- 13.頚動脈海綿静脈洞瘻の1例
- 15.Recklinghausen病に合併した頭皮下の巨大神経線維腫の2例
- 8.腫瘍と鑑別を要した器質化海綿状血管腫の一例
- 視神経管骨折に対する外科的治療
- 運動領野硬膜外刺激電極留置の工夫