<原著>ラットDMBA乳癌に対するchemo-endocrine therapyに関する実験的研究 : とくにestrogen receptor組織化学的検討を中心として
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The experimental studies of mechanism of chemo-endocrine therapy were made on histological ER activities (PAP method) and biochemical ER values (DCC method) before and after individual treatments, as well as on the tumor effect and histological changes on the DMBA-induced rat mammary carcinomas. DMBA-treated rats used consist of the following six groups ; (1) 23 rats with ovariectomy (Ovx group), (2) 26 rats with mitomycin C (MMC group), (3) 20 rats with cyclophosphamide (CPA group), and (4) 22 rats with tamoxifen (TAM group), (5) 23 rats with Ovx+MMC and (6) 20 rats with TAM+MMC. The tumor effect was most remarkable in Ovx+MMC group where the response rate was 91.3%. The response rate was secondarily highest in MMC group at 61.5%, followed by that in Ovx group at 60.9% and TAM+MMC group at 50.0%. After the therapy, histological ER activities became negative in 87.0% for Ovx+MMC group, 65.2% for Ovx group, 35.0% for TAM+MMC group, 18.2% for TAM group, 15.0% for CPA group and 11.5% for MMC group. Biochemical ER values lowered in all rats of Ovx+MMC group and Ovx group, tended to be lower in TAM group and CPA group, whereas they did not lower in MMC group, and the changes in biochemical ER levels were nearly consistent with those in histological ER activities. Among various histological changes of individual therapies, atrophy of the glands was observed more commonly in Ovx+MMC group and Ovx group (78.3% and 65.2%, respectively). Those areas showing such histological findings proved to have no more positive ER activities. Focal necrosis was observed in 46.2% of MMC group, and arborization of the glands like cactus in 45.5% of TAM group. Ovx+MMC group was thus found to show good effects for DMBA-induced rat mammary carcinoma. Therefore chemo-endocrine therapy seems to be more effective than the conservative ones for the treatment of breast cancer.
- 近畿大学の論文
- 1986-03-25
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