<原著>ラットDMH腸発癌の促進因子としての腸内細菌叢の影響
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After pedicled intestinal transposition in male SD rats, dimethyl hydrazine-dihydrochloride (DMH) carcinogenesis in the intestines was studied. The rates of carcinogenesis in the transposition groups were 90-100%, significantly higher than that in the non-operated control group. It was noteworthy that cancers were developed in the transposed ileal segment into the colon, not appearing in the ileum in normal and sham operation. The author has previously made clear that the carcinogenesis promoting change of the transposed ileum was epithelial hyperplasia. Thus, a factor bringing about this hyperplastic change may be thought to be a change in the intestinal microflora. In order to study the influences of intestinal microflora on the hyperplastic change in the transposed ileum, intestinal microflora was examined by a method of washing out the intestinal contents using a culture medium for bacterial examination. As for the result of the study of aerobes and anaerobes in the washing solution, compared with the non-operated control group, in the operated groups increases in quantity of aerobes and anaerobes were marked at each site of the intestinal tract. In the groups with the transposed intestine, the intestinal microflora increased at all sites, especially anastomosed sites, transposed ileum, and transposed colon sites. Using logarithmic expressions aerobes and facultative anaerobes were evaluated to be 5.95-7.29 and anaerobes 7.22-8.11 in 1 ml of the intestinal washing solution, the values showing a 10^3-10^5 increase compared with the control group. An increase in the quantity of bacteria and the predilection site of the cancer were nearly in agreement. Concerning the bacterial species, increases of E. coli, S. faecalis, Bacteroides, B. fragilis, Fusobacterium, etc. were observed. Especially, C. perfrigens and C. difficile, which were not detectable in the control, showed marked increases. It is entirely unsettled which bacteria, among these bacteria showing increases, has what influences on which part in the process of carcinogenesis, however, of the results the author obtained there are many points in agreement with the reports that increases in the bacterial quantities, especially of these bacterial species, were noted in the feces of patients with colon cancer. The problems of changes in the intestinal microflora and the intestinal epithelium must await future studies so as to be solved, and they are considered to be an important clue to the genesis of intestinal cancer.
- 近畿大学の論文
- 1986-03-25
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