<原著>ラットの結腸間有茎移植回腸上皮における組織学的および細胞動態学的研究 : DMH発癌の促進要因について

スポンサーリンク

概要

• 論文の詳細を見る

• It was found in our previous report that pedicled ileal segments transposed into the colon had an undoubted tendency to develop adenocarcinoma in the rat experiment with 1,2-dimethylhydrazine dihydrochloride (DMH), while the normal ileum has been reported to have the resistance against carcinogenesis. In order to clarify carcinogenic tendency of the transposed ileal segments, histological and cell kinetic changes of the pedicled transposed ileal segments without DMH were studied and the results are described in this report. Sprague-Dawley rats were divided into three groups : 1) transposed operation group ; an ileal segment was transposed into the distal colon, 2) sham transposed operation group ; an ileal segment was transected and reanastomosed in the same place and, 3) the third group served as the normal control. Cell kinetic study was performed by using labeling index (LI), mitotic index (MI), cell cycle, migration rate (MR), transit time (TT), and growth fraction (GF) with pulse labeling methods using ^3H-thymidine uptake. It was found that the number of crypt and villous epithelial cells was increased and the number of Paneth cells was reduced in pedicled transposed ileal segments. MI and LI in the transposed ileal segments were increased, compared with the normal ileum and the ileum of sham transposed operation. The proliferating zone was widened. Cell cycle time and DNA synthesizing time were prolonged. GF and MR were increased, and TT was shortened. The transposed ileal segments have similar cell kinetics to the normal ileum, more or less with hyperplastic tendency, than that of the normal ileum and the ileum of sham transposed operation. This hyperplastic tendency was deemed to be one of the promoting factors of carcinogenesis.

• 近畿大学の論文
• 1985-09-25

著者

• 桂 康博

  近畿大学医学部第一外科学教室

• 桂 康博

  近畿大学医学部第1外科学教室

関連論文

• DMH腸発癌におよぼす腸内細菌叢の影響に関する研究(1) : 腸手術の発癌に及ぼす影響, とくに腸内細菌量との関係について
• 肺癌の免疫血清学的診断法としての血清フェリチンの測定 I.CEA値との比較
• 15.先天性胆道拡張症の一例
• Mirizzi症候群の3例
• 消化器癌の肝転移に対する肝シンチグラフィーの診断能の評価
• 6.有茎移植腸管におけるDMH発癌の組織学的,粘液組織化学的,細胞動態学的研究
• 21.巨大後腹膜のう腫の1例
• 138 大腸癌のリンパ節検索における clearing 法とその評価(第20回日本消化器外科学会総会)
• 366 異所性胃および膵組織を伴った食道憩室の1例(第16回日本消化器外科学会総会)
• 9.N-methyl-N'-nitro-N-nitrosoguanidine直腸内投与による発癌と大腸粘膜のDNA中のO^6-methylguanine量に関する研究
• ラットの結腸間有茎移植回腸上皮における組織学的および細胞動態学的研究 : DMH発癌の促進要因について

もっと見る 閉じる

スポンサーリンク