SHRの心筋呼吸代謝に関する基礎的研究(A 基礎的研究)(I 発生病理)

概要

論文の詳細を見る
An investigation has been being performed in regard to the myocardial metabolism under ischemic state in both the non-hypertrophic (Wistar-Kyoto) and hypertrophic heart (SHR) to elucidate the effective myocardial protection under complete cardiac arrest by the coronary blood flow occlusion in clinical open heart surgery for the hypertrophic heart. Using a new fluorometric method has made it possible to observe the redox state of pyridine nucleotide (NAD), and electron transporter in mitchondria, and to evaluate non-invasively myocardial viability. The redox state of intramyocardial NAD had a close correlation with the level of intramyocardial ATP at the time of coronary re-perfusion. Furthermore, we would like to investigate the difference between myocardial metabolism in the hypertrophic heart and that in the nonhypertrophic heart after long time coronary blood flow occlusion and find effective factors in various cardioplegic methods to protect the myocardium of hypertrophic heart.
近畿大学の論文
1980-09-25