<原著>酵素抗体法による癌胎児性抗原(CEA)の細胞組織化学的研究(II) : フォルマリン固定による各種大腸病変におけるCEAの局在性について

概要

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Cytochemical and histochemical studies on CEA of the large intestine by using immunoperoxidase technique were conducted the 122 specimens included normal mucosae, hyperplastic mucosae, adenoma and cancer of the large intestine, which were available as paraffin-embedded tissues fixed in formalin. (1) Among 76 large bowel carcinomas, all of 67 differentiated adenocarcinomas showed positive staining for CEA, which were located at the apical border of the glandular cells. In 3 signet ring cell carcinomas, CEA was observed as an intracellular granules. While, one case of squamous cell carcinoma proved for CEA. (2) None of the normal mucosae and the mucosae adjacent to carcinoma or adenoma were positive for CEA. (3) In 42 adenomas of the large intestine, there existed a definite correlation between the intensity of CEA staining and the degree of epithelial atypicality, and severe atypicalities of adenoma were accompanied by the increase in CEA activity. The immunoperoxidase staining for CEA in the mucigen granules of the goblet cells was only positive as frozen sections and not after formalin-paraffin processed.
近畿大学の論文
1979-06-25