<Abstract of published report>Reduction of Drug Ketones by Dihydrodiol Dehydrogenases, Carbonyl Reductase and Aldehyde Reductase of Human Liver.
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概要
著者
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Hara A
Department Of Pathology Gifu University School Of Medicine
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Hara Akira
Department Of Pathology Gifu University School Of Medicine
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Hara A
Department Of Tumor Pathology Gifu University Graduate School Of Medicine
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Hara Akira
Department Of Tumor Pathology Gifu University Graduate School Of Medicine
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Matsuura Kazuya
岐阜薬科大学 生化
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Hara Akira
岐阜薬科大学
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Deyashiki Yoshihiro
Laboratory Of Biochemistry Gifu Pharmaceutical University
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Hara Akira
Biochemistry Laboratory Gifu Pharmaceutical University
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Matsuura Kazuya
Biochemistry Laboratory Gifu Pharmaceutical University
関連論文
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- Chemoprevention of Azoxymethane-induced Rat Colon Carcinogenesis by a Xanthine Oxidase Inhibitor, 1'-Acetoxychavicol Acetate.
- A Xanthine Oxiedase Inhibitor 1'-Acetoxychavicol Acetate Inhibits Azoxymethane-induced Colonic Aberrant Crypt Foci in Rats.
- Substrate Specificity of Human 3(20)α-Hydroxysteroid Dehydrogenase for Neurosteroids and Its Inhibition by Benzodiazepines
- Structure-specific Effcects of Thyroxine Analogs on Human Liver 3α-Hydroxysteroid Dehydrogenase.
- Dual Effect of Anti-inflammatory 2-Arylpropionic Acid Derivatives on a Major Isoform of Human Liver 3α-Hydroxysteroid Dehydrogenase.
- Dual Effects of Anti-inflammatory 2-Arylpropionic Acid Derivatives on a Major Isoform of Human Liver 3α-Hydroxysteroid Dehydrogenase
- Chemoprevention of Azoxymethane-induced Rat Colon Carcinogenesis by the Naturally Occurring Flavonoids, Diosmin and Hesperidin.
- Modulation of N-Methyl-N-amylnitrosamine-Induced Rat Oesphageal Tumourigenesis by Dietary Feeding of Diosmin and Sesperidine, Both Alone and in Combination.
- Aldehyde Dismutation Catalyzed by Pulmonary Carbonyl Reductase : Kinetic Studies of Chloral Hydrate Metabolism to Trichloroacetic Acid and Trichloroethanol.
- Structural and Functional Characterization of Rabbit and Human L-Gulonate 3-Dehydrogenase
- Characterization of Two Isoforms of Mouse 3(17)α-Hydroxysteroid Dehydrogenases of the Aldo-Keto Reductase Family(Biochemistry/Molecular Biology)
- Characterization of a Major Form of Human Isatin Reductase and the Reduced Metabolite.
- Molecular Cloning, Expression and Tissue Distribution of Hamster Diacetyl Reductase. : Identity with L-Xylulose.
- Enzymatic Characteristics and Subcellular Distribution of A Short-Chain Dehydrogenase/Reductase Family Protein, P26h, in Hamster Testis and epididymis.
- Crystallization and Preliminary X-ray Diffraction Analysis of Monkey Dimeric Dihydrodiol Dehydrogenase.
- Identity of Dimeric Dihydrodiol Dehydrogenase as NADP^+-dependent D-Xylose Dehydrogenase in Pig Liver.
- Roles of His-79 and Tyr-180 of D-Kylose/Dihydrodiol Dehydrogenase in Catalytic Function.
- Kinetic Alteration of Human Dihydrodiol/3α-Hydroxysteroid Dehydrogenase Isoenzyme, AKR1C4,by Replacement of Histidine-216 with Tyrosine or Phenylalanine.
- Structure-Specifis Effects of Thyroxine Analogs on Human Liver 3α-Hydroxysteroid Dehydrogenase
- Cloning and Sequencing of the cDNA Species for Mammalian Dimeric Dihydrodiol Dehydrogenases.
- Inhibition of Human Aldehyde Reductase by Drugs for Testing the Function of Liver and Kidney.
- Inhibition of Human Aldehyde Reductase by Drugs for Testing the Function of Liver and Kidney
- Roles of the C-Terminal Domains of Human Dihydrodiol Dehydrogenase Isoforms in the Binding of Substrates and Modulator : Probing with Chimaeric Enzymes.
- Sequence of the cDNA of a Human Dihydrodiol Dehydrogenase Isoform (AKR1C2) and Tissue Distribution of its mRNA.
- Activation of Human Liver 3α-Hydroxysteroid Dehydrogenase by Clofibrate Derivatives.
- Characterization of a Novel Variant (S145C/L311V) of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase in Human Liver.
- Chemopreventive Effect of N-(2-Cyclohexyloxy-4-nitrophenyl)methane Sulfonamide (NS-398), a Selective Cyclooxygenase-2 Inhibitor, in Rat Colon Carcinogenesis Induced by Azoxymethane
- Evidence for the Presence of Multiple Forms of Sph Kinase in Human Platelets.
- Molecular Cloning of a Gene Encoding Acid α-Glucosidase from Tetrahymena pyriformis.
- Chemical Modification of Cysteinyl, Lysyl and Histidyl Residues of Mouse Liver 17β-Hydroxysteroid Dehydrogenase.
- Structural and Functional Comparison of Two Human Liver Dihydrodiol Dehydrogenases Associated with 3α-Hydroxysteroid Dehydrogenase Activity.
- Purification and properties of multiple forms of dihydrodiol dehydrogenase from human liver.
- Purification of Cytosolic Estradiol 17β-Dehydrogenases from Male and Female Mouse Liver.
- Chemoprevention of 4-Nitroquinoline 1-Oxide-induced Oral Carcinogenesis in Rats by Flavonoids Diosmin and Hesperidin, Each Alone and in Combination.
- Changes in Blood Polyamine Levels Following Chemotherapy in Patients with Invasive Urinary Bladder Carcinoma.
- Identification of a Principal mRNA Species for Human 3α-Hydroxysteroid Dehydrogenase Isoform(AKR1C3) That Exhibits High Prostaglandin D_2 11-Ketoreductase Activity.
- Indentification of a Principal mRNA Species for Human 3α-Hydroxysteroid Dehydrogenase Isoform (AKR1C3) That Exhibits High Prostaglandin D_2 11-Ketoreductase Activity
- Changes in Tissue and Blood Polyamine Levels Following Chemotherapy in Rats with Urinary Bladder Carcinma Induced by N-Butyl-N-(4-hydroxybutyl)nitrosamine in Rats.
- Changes in Tissue and Blood Polyamines During N-Butyl-N-(4-hydroxybutyl)-nitrosoamine-induced Bladder Carcinogenesis in Rats.
- Identification of Amino Acid Residues Responsible for Difference in Substrate Specificity and Inhibitor Sensitivity Between Two Human Liver Dihydrodiol Dehydrogenase Isoenzymes by Site-directed Mutagenesis.
- Involvement of Two Basic Residues(Lys-270 and Arg-276)of Human Liver 3α-Hydroxysteroid Dehydrogenase in NADP(H)Binding and Actvation by Sulphobromophthalein : Site-directed Mutagenesis and Kinetic Analysis.
- Relationship of Human Liver Dihydrodiol Dehydrogenases to Hepatic Bile-Acid-Binding Protein and an Oxidoreductase of Human Colon Cells.
- 3-Deoxyglucosone Reductase in Dog Adrenal Glands. : Identification as Aldose Reductase.
- Molecular Cloning and Characterization of Mouse Estradiol 17β-Dehydrogenase(A-Specific), a Member of the Aldoketoreductase Family.
- Purification and Characterization of Dimeric Dihydrodiol Dehydrogenase from Dog Liver.
- Molecular Cloning of Two Human Liver 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isoenzymes That are Identical with Chlordecone Reductase and Bile-acid Binder.
- Purification and Characterization of a Novel Dimeric 20α-Hydroxysteroid Dehydrogenase from Tetrahymena Pyriformis.
- Stereospecificity of Trans-Dihydrodiol Oxidation by Dimeric and Monomeric Dihydrodiol Dehydrogenase from Mammalian Tissues.
- Monkey 3-Deoxyglucosone Reductase : Tissue Distribution, Purification of Three Multiple Forms of the Kidney Enzyme That Are Identical with Dihydrodiol Dehydrogenase, Aldehyde Reductase and Aldose Reductase.
- Cloning and Sequence Analysis of a cDNA Encoding Tetrameric Carbonyl Reductase of Pig Lung.
- Inhibition of Human Placenta Aldose Reductase by Tannic Acid.
- Ultrastructual Localization of Carbonyl Reductase in Mouse Lung.
- Modification of Pig Liver Dimeric Dihydrodiol Dehydrogenase with Diethylpyrocarbonate and by Rose Bengal-Sensitized Photooxidation-Evidence for an Active-Site Histidine Residue.
- Activation of Carbonyl Reductase from Pig Lung by Fatty Acids.
- Purification and Characterization of Pig Lung Carbonyl Reductase.
- Inhibition of Dimeric Dihydrodiol Dehydrogenases of Rabbit and Pig Lens by Ascorbic Acid.
- Distribution and Characterization of Dihydrodiol Dehydrogenases in Mammalian Ocular Tisues.
- Kinetic and Stereochemical Characterization of Hamster Liver 3α-Hydroxysteroid Dehydrogenase and 3α(17β)-Hydroxysteroid Dehydrogenase.
- Aldehyde Reductase is a Major Protein Associated with 3-Deoxyglucosone Reductase Activity in Rat, Pig and Human Livers.
- Localization of pulmonary carbonyl reductase in guinea pig and mouse : Enzyme histochemical and immunochemical studies.
- Isolation from Pig Lens of Two Proteins with Dihydrodiol Dehydrogenase and Aldehyde Reductase Activities.
- Dimeric Dihydrodiol Dehydrogenase in Monkey Kidney. : Substrate Specificity, Stereospecificity of Hydrogen Transfer, and Distribution.
- Identification of Two Dihydrodiol Dehydrogenases Associated with 3(17)α-Hydroxysteroid Dehydrogenase Activity in Mouse Kidney.
- Purification and Properties of Multiple Forms of Dihydrodiol Dehydrogenase from Monkey Liver.
- Aldose Reductase is a Major Reductase for Isocaproaldehyde, a Product of Side-Chain Cleavage of Cholesterol, in Human and Animal Adrenal Glands.
- CHARACTERIZATION OF DIHYDRODIOL DEHYDROGENASES IN MONKEY TISSUES
- A Sensitive Fluorometric Assay for Dihydrodiol Dehydrogenase.
- Switch of Coenzyme Specificity of Mouse Lung Carbonyl Reductase by Substitution of Threonine 38 with Aspartic Acid.
- Involvement of Two Basic Residues (Lys-17 and Arg-39) of Mouse Lung Carbonyl Reductase in NADP(H)-Binding and Fatty Acid Activation : Site-Directed Mutagenesis and Kinetic Analyses.
- Activation of Human Liver 3α-Hydroxysteroid Dehydrogenase by Sulphobromophthalein.
- Microcystic Meningioma Without Enhancement on Neuroimaging : Case Report
- Identification of Lactaldehyde Reductase and Aldehyde Reductase as Functions of the Same Enzyme Protein in Pig Kidney
- Involvement of Two Basic Residues (Lys-17 and Arg-39) of Mouse Lung Carbonyl Reductase in NADP(H)-Binding and Fatty Acid Activation: Site-Directed Mutagenesis and Kinetic Analyses
- Crystal Structure of Ternary Complex of Mouse Lung Carbonyl Reductase at 1.8Å Resolution : the Structural Origin of Coenzyme Specificity in the Short-Chain Dehydrogenase/Reductase Family.
- Crystalization of Mouse Lung Carbonyl Reductase Complexed with NADPH and Analysis of Symmetry of its Tetrametic Molecule.
- Over-expression of Pig Lung Carbonyl Reductase in Escherichia Coli.
- Expression and kinetic Properties of a Recombinant 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isenzyme of Human Liver.
- Cloning, Expression and Tissue Distribution of Mouse Tetrameric Carbonyl Reductase. : Identity with an Adipocyte 27-kDa Protein.
- Reduction of Prostaglandin D_2 to 9α, 11β-Prostaglandin F_2 by a Human Liver 3α-Hydroxysteroid/Dihydorodiol Dehydrogenase Isozyme.
- Purification and Characterization of NADP-dependent 3α-Hydroxysteroid Dehydrogenase from Mouse Liver Cyotosol.
- Mouse Liver Dihydrodiol Dehydrogenases. : Identity of the Predominant and a Minor Form with 17β-Hydroxysteroid Dehydrogenase and Aldehyde Reductase
- Crystallzation of Mouse Lung Carbonyl Reductase Complexed with NADPH and Analyssi of Symmetry of Its Tetrameric Moloucle
- Reduction of Drug Ketones by Dihydrodiol Dehydrogenases, Carbonyl Reductase and Aldehyde Reductase of Human Liver.
- Kinetic Studies of the Inhibition of a Human Liver 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isozyme by Bile Acids and Anti-inflammatory Drugs.
- Expression and Kinetic Properties of a Recombinant 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isoenzyme of Human Liver
- Inhibition of Dimeric Dihydrodiol Dehydrogenase by 4-Hydroxyphenylketone Derivatives : Aspects of Inhibitor Structure and Binding Specificity.
- Characterization of Pulmonary Carbonyl Reductase of Mouse and Guinea Pig.
- Monkey Liver Indanol Dehydrogenase. : Purification, Properties, and Kinetic Mechaniem.
- Separation and Properties of Multiple Forms of Dihydrodiol Dehydrogenase from Hamster Liver.
- Kinetic Mechanism of Pulmonary Carbonyl Reductase
- Subcellular Distribution and Properties of Carbonyl Reductase in Guniea Pig Lung.
- Purification and Properties of Two Multiple Forms of Dihydrodiol Dehydrogenase from Guinea-Pig Testis.
- Carbonyl Reductase of Dog Liver : Purification, Properties, and Kinetic Mechanism.
- Dihydrodiol Dehydrogenases in Guinea Pig Liver.
- Crystallization of Mouse Lung Carbonyl Reductase Complexed with NADPH and Analysis of Symmetry of Its Tetrameric Molecule.