Expression and Kinetic Properties of a Recombinant 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isoenzyme of Human Liver

スポンサーリンク

概要

• 論文の詳細を見る
• 1995-08-01

著者

• Hara Akira

  Department Of Pathology Gifu University School Of Medicine

• Hara A

  Department Of Tumor Pathology Gifu University Graduate School Of Medicine

• MATSUURA Kazuya

  Biochemistry Laboratory, Gifu Pharmaceutical University

• DEYASHIKI Yoshihiro

  Biochemistry Laboratory, Gifu Pharmaceutical University

• HARA Akira

  Biochemistry Laboratory, Gifu Pharmaceutical University

• Matsuura Kazuya

  岐阜薬科大学 生化

• Hara Akira

  岐阜薬科大学

• TAMADA Yoshiyuki

  Biochemistry Laboratory, Gifu Pharmaceutical University

• MIYABE Yoshiyuki

  Biochemistry Laboratory, Gifu Pharmaceutical University

• NAKANISHI Masayuki

  Biochemistry Laboratory, Gifu Pharmaceutical University

• Nakanishi M

  Laboratory Of Molecular Biochemistry Department Of Biomolecular Science Faculty Of Engineering Gifu

• Hara Akira

  Biochemistry Laboratory Gifu Pharmaceutical University

• Matsuura Kazuya

  Biochemistry Laboratory Gifu Pharmaceutical University

関連論文

• Substrate Specificity of Human 3(20)α-Hydroxysteroid Dehydrogenase for Neurosteroids and Its Inhibition by Benzodiazepines
• Structure-specific Effcects of Thyroxine Analogs on Human Liver 3α-Hydroxysteroid Dehydrogenase.
• Dual Effect of Anti-inflammatory 2-Arylpropionic Acid Derivatives on a Major Isoform of Human Liver 3α-Hydroxysteroid Dehydrogenase.
• Dual Effects of Anti-inflammatory 2-Arylpropionic Acid Derivatives on a Major Isoform of Human Liver 3α-Hydroxysteroid Dehydrogenase
• Aldehyde Dismutation Catalyzed by Pulmonary Carbonyl Reductase : Kinetic Studies of Chloral Hydrate Metabolism to Trichloroacetic Acid and Trichloroethanol.
• Structural and Functional Characterization of Rabbit and Human L-Gulonate 3-Dehydrogenase
• Characterization of Two Isoforms of Mouse 3(17)α-Hydroxysteroid Dehydrogenases of the Aldo-Keto Reductase Family(Biochemistry/Molecular Biology)
• Characterization of a Major Form of Human Isatin Reductase and the Reduced Metabolite.
• Molecular Cloning, Expression and Tissue Distribution of Hamster Diacetyl Reductase. : Identity with L-Xylulose.
• Enzymatic Characteristics and Subcellular Distribution of A Short-Chain Dehydrogenase/Reductase Family Protein, P26h, in Hamster Testis and epididymis.
• Crystallization and Preliminary X-ray Diffraction Analysis of Monkey Dimeric Dihydrodiol Dehydrogenase.
• Identity of Dimeric Dihydrodiol Dehydrogenase as NADP^+-dependent D-Xylose Dehydrogenase in Pig Liver.
• Roles of His-79 and Tyr-180 of D-Kylose/Dihydrodiol Dehydrogenase in Catalytic Function.
• Kinetic Alteration of Human Dihydrodiol/3α-Hydroxysteroid Dehydrogenase Isoenzyme, AKR1C4,by Replacement of Histidine-216 with Tyrosine or Phenylalanine.
• Structure-Specifis Effects of Thyroxine Analogs on Human Liver 3α-Hydroxysteroid Dehydrogenase
• Cloning and Sequencing of the cDNA Species for Mammalian Dimeric Dihydrodiol Dehydrogenases.
• Inhibition of Human Aldehyde Reductase by Drugs for Testing the Function of Liver and Kidney.
• Inhibition of Human Aldehyde Reductase by Drugs for Testing the Function of Liver and Kidney
• Roles of the C-Terminal Domains of Human Dihydrodiol Dehydrogenase Isoforms in the Binding of Substrates and Modulator : Probing with Chimaeric Enzymes.
• Sequence of the cDNA of a Human Dihydrodiol Dehydrogenase Isoform (AKR1C2) and Tissue Distribution of its mRNA.
• Activation of Human Liver 3α-Hydroxysteroid Dehydrogenase by Clofibrate Derivatives.
• Characterization of a Novel Variant (S145C/L311V) of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase in Human Liver.
• Molecular Cloning of a Gene Encoding Acid α-Glucosidase from Tetrahymena pyriformis.
• Chemical Modification of Cysteinyl, Lysyl and Histidyl Residues of Mouse Liver 17β-Hydroxysteroid Dehydrogenase.
• Structural and Functional Comparison of Two Human Liver Dihydrodiol Dehydrogenases Associated with 3α-Hydroxysteroid Dehydrogenase Activity.
• Purification and properties of multiple forms of dihydrodiol dehydrogenase from human liver.
• Purification of Cytosolic Estradiol 17β-Dehydrogenases from Male and Female Mouse Liver.
• Changes in Blood Polyamine Levels Following Chemotherapy in Patients with Invasive Urinary Bladder Carcinoma.
• Identification of a Principal mRNA Species for Human 3α-Hydroxysteroid Dehydrogenase Isoform(AKR1C3) That Exhibits High Prostaglandin D_2 11-Ketoreductase Activity.
• Indentification of a Principal mRNA Species for Human 3α-Hydroxysteroid Dehydrogenase Isoform (AKR1C3) That Exhibits High Prostaglandin D_2 11-Ketoreductase Activity
• Changes in Tissue and Blood Polyamine Levels Following Chemotherapy in Rats with Urinary Bladder Carcinma Induced by N-Butyl-N-(4-hydroxybutyl)nitrosamine in Rats.
• Changes in Tissue and Blood Polyamines During N-Butyl-N-(4-hydroxybutyl)-nitrosoamine-induced Bladder Carcinogenesis in Rats.
• Identification of Amino Acid Residues Responsible for Difference in Substrate Specificity and Inhibitor Sensitivity Between Two Human Liver Dihydrodiol Dehydrogenase Isoenzymes by Site-directed Mutagenesis.
• Involvement of Two Basic Residues(Lys-270 and Arg-276)of Human Liver 3α-Hydroxysteroid Dehydrogenase in NADP(H)Binding and Actvation by Sulphobromophthalein : Site-directed Mutagenesis and Kinetic Analysis.
• Relationship of Human Liver Dihydrodiol Dehydrogenases to Hepatic Bile-Acid-Binding Protein and an Oxidoreductase of Human Colon Cells.
• 3-Deoxyglucosone Reductase in Dog Adrenal Glands. : Identification as Aldose Reductase.
• Molecular Cloning and Characterization of Mouse Estradiol 17β-Dehydrogenase(A-Specific), a Member of the Aldoketoreductase Family.
• Purification and Characterization of Dimeric Dihydrodiol Dehydrogenase from Dog Liver.
• Molecular Cloning of Two Human Liver 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isoenzymes That are Identical with Chlordecone Reductase and Bile-acid Binder.
• Purification and Characterization of a Novel Dimeric 20α-Hydroxysteroid Dehydrogenase from Tetrahymena Pyriformis.
• Stereospecificity of Trans-Dihydrodiol Oxidation by Dimeric and Monomeric Dihydrodiol Dehydrogenase from Mammalian Tissues.
• Monkey 3-Deoxyglucosone Reductase : Tissue Distribution, Purification of Three Multiple Forms of the Kidney Enzyme That Are Identical with Dihydrodiol Dehydrogenase, Aldehyde Reductase and Aldose Reductase.
• Cloning and Sequence Analysis of a cDNA Encoding Tetrameric Carbonyl Reductase of Pig Lung.
• Inhibition of Human Placenta Aldose Reductase by Tannic Acid.
• Ultrastructual Localization of Carbonyl Reductase in Mouse Lung.
• Modification of Pig Liver Dimeric Dihydrodiol Dehydrogenase with Diethylpyrocarbonate and by Rose Bengal-Sensitized Photooxidation-Evidence for an Active-Site Histidine Residue.
• Activation of Carbonyl Reductase from Pig Lung by Fatty Acids.
• Purification and Characterization of Pig Lung Carbonyl Reductase.
• Inhibition of Dimeric Dihydrodiol Dehydrogenases of Rabbit and Pig Lens by Ascorbic Acid.
• Distribution and Characterization of Dihydrodiol Dehydrogenases in Mammalian Ocular Tisues.
• Kinetic and Stereochemical Characterization of Hamster Liver 3α-Hydroxysteroid Dehydrogenase and 3α(17β)-Hydroxysteroid Dehydrogenase.
• Aldehyde Reductase is a Major Protein Associated with 3-Deoxyglucosone Reductase Activity in Rat, Pig and Human Livers.
• Localization of pulmonary carbonyl reductase in guinea pig and mouse : Enzyme histochemical and immunochemical studies.
• Isolation from Pig Lens of Two Proteins with Dihydrodiol Dehydrogenase and Aldehyde Reductase Activities.
• Dimeric Dihydrodiol Dehydrogenase in Monkey Kidney. : Substrate Specificity, Stereospecificity of Hydrogen Transfer, and Distribution.
• Identification of Two Dihydrodiol Dehydrogenases Associated with 3(17)α-Hydroxysteroid Dehydrogenase Activity in Mouse Kidney.
• Purification and Properties of Multiple Forms of Dihydrodiol Dehydrogenase from Monkey Liver.
• Aldose Reductase is a Major Reductase for Isocaproaldehyde, a Product of Side-Chain Cleavage of Cholesterol, in Human and Animal Adrenal Glands.
• CHARACTERIZATION OF DIHYDRODIOL DEHYDROGENASES IN MONKEY TISSUES
• A Sensitive Fluorometric Assay for Dihydrodiol Dehydrogenase.
• Switch of Coenzyme Specificity of Mouse Lung Carbonyl Reductase by Substitution of Threonine 38 with Aspartic Acid.
• Involvement of Two Basic Residues (Lys-17 and Arg-39) of Mouse Lung Carbonyl Reductase in NADP(H)-Binding and Fatty Acid Activation : Site-Directed Mutagenesis and Kinetic Analyses.
• Activation of Human Liver 3α-Hydroxysteroid Dehydrogenase by Sulphobromophthalein.
• Microcystic Meningioma Without Enhancement on Neuroimaging : Case Report
• Identification of Lactaldehyde Reductase and Aldehyde Reductase as Functions of the Same Enzyme Protein in Pig Kidney
• Involvement of Two Basic Residues (Lys-17 and Arg-39) of Mouse Lung Carbonyl Reductase in NADP(H)-Binding and Fatty Acid Activation: Site-Directed Mutagenesis and Kinetic Analyses
• Crystal Structure of Ternary Complex of Mouse Lung Carbonyl Reductase at 1.8Å Resolution : the Structural Origin of Coenzyme Specificity in the Short-Chain Dehydrogenase/Reductase Family.
• Crystalization of Mouse Lung Carbonyl Reductase Complexed with NADPH and Analysis of Symmetry of its Tetrametic Molecule.
• Over-expression of Pig Lung Carbonyl Reductase in Escherichia Coli.
• Expression and kinetic Properties of a Recombinant 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isenzyme of Human Liver.
• Cloning, Expression and Tissue Distribution of Mouse Tetrameric Carbonyl Reductase. : Identity with an Adipocyte 27-kDa Protein.
• Reduction of Prostaglandin D_2 to 9α, 11β-Prostaglandin F_2 by a Human Liver 3α-Hydroxysteroid/Dihydorodiol Dehydrogenase Isozyme.
• Purification and Characterization of NADP-dependent 3α-Hydroxysteroid Dehydrogenase from Mouse Liver Cyotosol.
• Mouse Liver Dihydrodiol Dehydrogenases. : Identity of the Predominant and a Minor Form with 17β-Hydroxysteroid Dehydrogenase and Aldehyde Reductase
• Crystallzation of Mouse Lung Carbonyl Reductase Complexed with NADPH and Analyssi of Symmetry of Its Tetrameric Moloucle
• Comparative Study on the Biological Properties of 2,5-Oligoadenylate Derivatives with Purified Human RNase L Expressed in E.coli
• Reduction of Drug Ketones by Dihydrodiol Dehydrogenases, Carbonyl Reductase and Aldehyde Reductase of Human Liver.
• Kinetic Studies of the Inhibition of a Human Liver 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isozyme by Bile Acids and Anti-inflammatory Drugs.
• Expression and Kinetic Properties of a Recombinant 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isoenzyme of Human Liver
• Inhibition of Dimeric Dihydrodiol Dehydrogenase by 4-Hydroxyphenylketone Derivatives : Aspects of Inhibitor Structure and Binding Specificity.
• Characterization of Pulmonary Carbonyl Reductase of Mouse and Guinea Pig.
• Monkey Liver Indanol Dehydrogenase. : Purification, Properties, and Kinetic Mechaniem.
• Separation and Properties of Multiple Forms of Dihydrodiol Dehydrogenase from Hamster Liver.
• Kinetic Mechanism of Pulmonary Carbonyl Reductase
• Subcellular Distribution and Properties of Carbonyl Reductase in Guniea Pig Lung.
• Purification and Properties of Two Multiple Forms of Dihydrodiol Dehydrogenase from Guinea-Pig Testis.
• Purification and Properties of Recombinant Plasmodium falciparum S-Adenosyl-L-Homocysteine Hydrolase^1
• Dihydrodiol Dehydrogenases in Guinea Pig Liver.

もっと見る 閉じる

スポンサーリンク