<Abstract of published report>Inhibition of Dimeric Dihydrodiol Dehydrogenases of Rabbit and Pig Lens by Ascorbic Acid.

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概要

• 論文の詳細を見る
• 岐阜薬科大学の論文
• 1992-06-30

著者

• Kanazu T

  Shionogi & Co. Ltd. Osaka Jpn

• Hara Akira

  岐阜薬科大学

• Deyashiki Yoshihiro

  Laboratory Of Biochemistry Gifu Pharmaceutical University

関連論文

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• Dual Effect of Anti-inflammatory 2-Arylpropionic Acid Derivatives on a Major Isoform of Human Liver 3α-Hydroxysteroid Dehydrogenase.
• Dual Effects of Anti-inflammatory 2-Arylpropionic Acid Derivatives on a Major Isoform of Human Liver 3α-Hydroxysteroid Dehydrogenase
• Aldehyde Dismutation Catalyzed by Pulmonary Carbonyl Reductase : Kinetic Studies of Chloral Hydrate Metabolism to Trichloroacetic Acid and Trichloroethanol.
• Roles of the C-Terminal Domains of Human Dihydrodiol Dehydrogenase Isoforms in the Binding of Substrates and Modulator : Probing with Chimaeric Enzymes.
• Sequence of the cDNA of a Human Dihydrodiol Dehydrogenase Isoform (AKR1C2) and Tissue Distribution of its mRNA.
• Activation of Human Liver 3α-Hydroxysteroid Dehydrogenase by Clofibrate Derivatives.
• Chemical Modification of Cysteinyl, Lysyl and Histidyl Residues of Mouse Liver 17β-Hydroxysteroid Dehydrogenase.
• Structural and Functional Comparison of Two Human Liver Dihydrodiol Dehydrogenases Associated with 3α-Hydroxysteroid Dehydrogenase Activity.
• Purification and properties of multiple forms of dihydrodiol dehydrogenase from human liver.
• Identification of a Principal mRNA Species for Human 3α-Hydroxysteroid Dehydrogenase Isoform(AKR1C3) That Exhibits High Prostaglandin D_2 11-Ketoreductase Activity.
• Indentification of a Principal mRNA Species for Human 3α-Hydroxysteroid Dehydrogenase Isoform (AKR1C3) That Exhibits High Prostaglandin D_2 11-Ketoreductase Activity
• Identification of Amino Acid Residues Responsible for Difference in Substrate Specificity and Inhibitor Sensitivity Between Two Human Liver Dihydrodiol Dehydrogenase Isoenzymes by Site-directed Mutagenesis.
• Involvement of Two Basic Residues(Lys-270 and Arg-276)of Human Liver 3α-Hydroxysteroid Dehydrogenase in NADP(H)Binding and Actvation by Sulphobromophthalein : Site-directed Mutagenesis and Kinetic Analysis.
• Relationship of Human Liver Dihydrodiol Dehydrogenases to Hepatic Bile-Acid-Binding Protein and an Oxidoreductase of Human Colon Cells.
• 3-Deoxyglucosone Reductase in Dog Adrenal Glands. : Identification as Aldose Reductase.
• Molecular Cloning and Characterization of Mouse Estradiol 17β-Dehydrogenase(A-Specific), a Member of the Aldoketoreductase Family.
• Purification and Characterization of Dimeric Dihydrodiol Dehydrogenase from Dog Liver.
• Molecular Cloning of Two Human Liver 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isoenzymes That are Identical with Chlordecone Reductase and Bile-acid Binder.
• Purification and Characterization of a Novel Dimeric 20α-Hydroxysteroid Dehydrogenase from Tetrahymena Pyriformis.
• Stereospecificity of Trans-Dihydrodiol Oxidation by Dimeric and Monomeric Dihydrodiol Dehydrogenase from Mammalian Tissues.
• Monkey 3-Deoxyglucosone Reductase : Tissue Distribution, Purification of Three Multiple Forms of the Kidney Enzyme That Are Identical with Dihydrodiol Dehydrogenase, Aldehyde Reductase and Aldose Reductase.
• Cloning and Sequence Analysis of a cDNA Encoding Tetrameric Carbonyl Reductase of Pig Lung.
• Inhibition of Human Placenta Aldose Reductase by Tannic Acid.
• Purification and Characterization of Purple Acid Phosphatase from Rat Bone.
• Ultrastructual Localization of Carbonyl Reductase in Mouse Lung.
• Modification of Pig Liver Dimeric Dihydrodiol Dehydrogenase with Diethylpyrocarbonate and by Rose Bengal-Sensitized Photooxidation-Evidence for an Active-Site Histidine Residue.
• Activation of Carbonyl Reductase from Pig Lung by Fatty Acids.
• Purification and Characterization of Pig Lung Carbonyl Reductase.
• Inhibition of Dimeric Dihydrodiol Dehydrogenases of Rabbit and Pig Lens by Ascorbic Acid.
• Distribution and Characterization of Dihydrodiol Dehydrogenases in Mammalian Ocular Tisues.
• Kinetic and Stereochemical Characterization of Hamster Liver 3α-Hydroxysteroid Dehydrogenase and 3α(17β)-Hydroxysteroid Dehydrogenase.
• Aldehyde Reductase is a Major Protein Associated with 3-Deoxyglucosone Reductase Activity in Rat, Pig and Human Livers.
• Isolation from Pig Lens of Two Proteins with Dihydrodiol Dehydrogenase and Aldehyde Reductase Activities.
• Identification of Two Dihydrodiol Dehydrogenases Associated with 3(17)α-Hydroxysteroid Dehydrogenase Activity in Mouse Kidney.
• Purification and Properties of Multiple Forms of Dihydrodiol Dehydrogenase from Monkey Liver.
• Aldose Reductase is a Major Reductase for Isocaproaldehyde, a Product of Side-Chain Cleavage of Cholesterol, in Human and Animal Adrenal Glands.
• A Sensitive Fluorometric Assay for Dihydrodiol Dehydrogenase.
• Switch of Coenzyme Specificity of Mouse Lung Carbonyl Reductase by Substitution of Threonine 38 with Aspartic Acid.
• Involvement of Two Basic Residues (Lys-17 and Arg-39) of Mouse Lung Carbonyl Reductase in NADP(H)-Binding and Fatty Acid Activation : Site-Directed Mutagenesis and Kinetic Analyses.
• Activation of Human Liver 3α-Hydroxysteroid Dehydrogenase by Sulphobromophthalein.
• Identification of Lactaldehyde Reductase and Aldehyde Reductase as Functions of the Same Enzyme Protein in Pig Kidney
• Crystal Structure of Ternary Complex of Mouse Lung Carbonyl Reductase at 1.8Å Resolution : the Structural Origin of Coenzyme Specificity in the Short-Chain Dehydrogenase/Reductase Family.
• Crystalization of Mouse Lung Carbonyl Reductase Complexed with NADPH and Analysis of Symmetry of its Tetrametic Molecule.
• Over-expression of Pig Lung Carbonyl Reductase in Escherichia Coli.
• Expression and kinetic Properties of a Recombinant 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isenzyme of Human Liver.
• Cloning, Expression and Tissue Distribution of Mouse Tetrameric Carbonyl Reductase. : Identity with an Adipocyte 27-kDa Protein.
• Reduction of Prostaglandin D_2 to 9α, 11β-Prostaglandin F_2 by a Human Liver 3α-Hydroxysteroid/Dihydorodiol Dehydrogenase Isozyme.
• Crystallzation of Mouse Lung Carbonyl Reductase Complexed with NADPH and Analyssi of Symmetry of Its Tetrameric Moloucle
• Reduction of Drug Ketones by Dihydrodiol Dehydrogenases, Carbonyl Reductase and Aldehyde Reductase of Human Liver.
• Kinetic Studies of the Inhibition of a Human Liver 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isozyme by Bile Acids and Anti-inflammatory Drugs.
• Expression and Kinetic Properties of a Recombinant 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Isoenzyme of Human Liver
• Inhibition of Dimeric Dihydrodiol Dehydrogenase by 4-Hydroxyphenylketone Derivatives : Aspects of Inhibitor Structure and Binding Specificity.
• Carbonyl Reductase of Dog Liver : Purification, Properties, and Kinetic Mechanism.
• Crystallization of Mouse Lung Carbonyl Reductase Complexed with NADPH and Analysis of Symmetry of Its Tetrameric Molecule.

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