MORPHOLOGICAL TRAITS, CELL PROLIFERATION AND APOPTOSIS IN ADRENOCORTICAL X-ZONE IN PREGNANT MICE
スポンサーリンク
概要
- 論文の詳細を見る
Adrenocortical X-zone, a transitory cortical region in virgin female and immature male, exists exclusively in mice, and its detailed nature, regression and turnover remain unclear. In this study, the X-zone was investigated in pregnant Jcl : ICR mice, in aspects of morphological traits, cell proliferation by bromodeoxyuridine (BrdU) immunohistochemistry and apoptosis by in situ nick endlabeling of genomic DNA (TUNEL). In the early pregnancy, the intact X-zone, which took more than 30% of the total adrenocortex, was composed exclusively of non-vacuolated cells, with smaller size and a darker nuclei than other permanent cortical cells. From day 8 of gestation, the X-zone involuted gradually and this degeneration process lasted about one week. There are similarities and discrepancies between Jcl : ICR mice and reported other strains in cellular composition and period of the involution, suggesting strain-difference due to genetic background. BrdU immunohistochemistry demonstrated an apparently more active cell proliferation in the intact X-zone than in other permanent cortical zones. Apoptotic cells were not observed during the X-zone involution by either hematoxylin-eosin staining or TUNEL.
- 島根大学の論文
著者
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Zhang H
School Of Pharmacy Sichuan University
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Zhang Hao
Department Of Anatomy Shimane Medical University
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Zhang H
Shimane Medical Univ. Izumo Jpn
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Zhang Hao
Division Of Hepatology And Metabolism Department Of Internal Medicine Saga Medical School Saga Unive
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ZHANG Hao
First Division, Department of Anatomy, Shimane Medical University
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MA Lang
First Division, Department of Anatomy, Shimane Medical University
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OTANI Hiroki
First Division, Department of Anatomy, Shimane Medical University
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MATSUMOTO Akihiro
First Division, Department of Anatomy, Shimane Medical University
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HATTA Toshihisa
First Division, Department of Anatomy, Shimane Medical University
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Ma Lang
Department Of Anatomy Shimane Medical University
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Hatta Toshihisa
Department Of Anatomy Shimane University Faculty Of Medicine
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Otani H
Shimane Medical Univ. Izumo Jpn
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Otani H
Department Of Anatomy Shimane University Faculty Of Medicine
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Otani Hiroki
First Division Department Of Anatomy Shimane Medical University
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Matsumoto Akihiro
Department Of Developmental Biology Faculty Of Medicine Shimane University
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Ma Lang
First Division Department Of Anatomy Shimane Medical University
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Zhang Hao
First Division Department Of Anatomy Shimane Medical University
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Matsumoto Akihiro
First Division Department Of Anatomy Shimane Medical University
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Hatta Toshihisa
First Division Department Of Anatomy Shimane Medical University
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