<Originals>Effect of reperfusion 12 hours after coronary occlusion on myocardial salvage in dogs
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概要
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Late reperfusion therapy in acute myocardial infarction (AMI) has been generally considered not effective on the salvage of myocardial necrosis. However, the salvage by late reperfusion would be possible if the development of necrosis was relatively late and the myocardium remained viable until reperfusion. To test this hypothesis, we performed the experiment of myocardial reperfusion 12 hours after occlusion of the left anterior descending coronary artery in dogs. Twenty five dogs were divided into two groups ; in group A (n=12) the artery remained occluded for 4 weeks and in group B (n=13) it was reperfused 12 hours after occlusion. Regional myocardial blood flow (Qm) was measured using the colored microsphere method. The heart was removed at 4 weeks, and three indices, consisting of myocardial creatine kinase activity (CK), infarct size determined by the triphenyl tetrazolium chloride (TTC) stain and histological extent of fibrosis, were measured to determine the extent of necrosis. In the inner layer, infarct size and myocardial CK showed no difference between the groups, while the extent of fibrosis was significantly less in group B than in group A. At the middle layer, although infarct size was similar in both groups, myocardial CK was higher in group B than in group A and the extent of fibrosis was less in the former than in the latter. A similar result was shown in the outer layer, where myocardial CK was greater in group B than in group A and the extent of fibrosis was less in the former than in the latter. A significant reduction of fibrosis in all 3 layers and a higher myocardial CK in the middle and outer layers in group B may be attributed to myocardial salvage by late reperfusion. Thus, it is suggested that late reperfusion therapy has beneficial effects on myocardial salvage in AMI.
- 近畿大学の論文
著者
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KAMATA NORIAKI
First Department of Internal Medicine, Kinki University School of Medicine
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Kamata Noriaki
First Department Of Internal Medicine Kinki University School Of Medicine
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