<Originals>Changes in activity of substantia nigra pars reticulata neurons after middle cerebral artery occlusion in the rat

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概要

• 論文の詳細を見る

• The spontaneous single unit activity of substantia nigra pars reticulata (SNR) neurons was studied in control and in ipsilateral middle cerebral artery (MCA)-occluded rats. The activity of MCA-occluded preparations was recorded in 3 groups ; 1 hour, 24 hours, and 7 days after MCA occlusion. Activity was recorded extracellularly with glass microelectrodes and was analyzed using time interval histograms. In the control, half of the SNR units (47%) showed a regular firing pattern. There was no change 1 hour after MCA occlusion. After 24 hours and 7 days, however, there was increased SNR neuronal unit activity with irregular firing patterns (67% and 57%, respectively), and a slightly decreased mean firing rate. In the MCA-occluded groups, no hyperexcited neurons at all were found in the SNR. Our results indicated that SNR neuronal degeneration accompanied by striatal ischemia does not depend simply on hyperexcitation due to a disinhibition mechanism.

• 近畿大学の論文

著者

• ASAI Toshiharu

  First Department of Physiology, Kinki University School of Medicine

• Asai Toshiharu

  First Department Of Physiology Kinki University School Of Medicine

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• Changes in activity of substantia nigra pars reticulata neurons after middle cerebral artery occlusion in the rat

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