Serum Blood Urea Nitrogen and Plasma Brain Natriuretic Peptide and Low Diastolic Blood Pressure Predict Cardiovascular Morbidity and Mortality Following Discharge in Acute Decompensated Heart Failure Patients
スポンサーリンク
概要
- 論文の詳細を見る
Background: Patients with heart failure (HF) have a high risk of cardiovascular (CV) death and re-hospitalization. The purpose of the present study was therefore to investigate predictors of CV death and re-hospitalization for acute decompensated HF (ADHF). Methods and Results: A total of 225 patients aged 67.2±15.2 years, including 134 men (59.6%), who were hospitalized for ADHF between 2008 and 2009, were followed up. After discharge, the relationship between clinical parameters and CV events (ie, CV death or re-hospitalization for HF) was examined. Follow-up was continued until 30 April 2011. The most important predictors of re-hospitalization were serum blood urea nitrogen (BUN; adjusted hazard ratio [HR], 1.02; 95% confidence interval [CI]: 1.00–1.03, P=0.01), plasma brain natriuretic peptide (BNP; adjusted HR, 1.85; 95% CI: 1.12–3.04, P=0.02), and diastolic blood pressure (DBP; adjusted HR, 0.97; 95% CI: 0.94–1.00, P=0.049). The only predictor of CV mortality was a high BUN (adjusted HR, 1.05; 95% CI: 1.01–1.09, P=0.01). Conclusions: High serum BUN (≥22.5mg/dl), high plasma BNP (≥250pg/ml), and low DBP (<60mmHg) predict CV events in patients hospitalized for ADHF. These factors may identify high-risk patients for CV events and provide therapeutic targets for managing HF. (Circ J 2012; 76: 2372–2379)
- 2012-09-25
著者
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Kawamoto Manabu
国立医薬品食品衛生研究所
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Kawamoto Manabu
Division Of Genomic Medicine Department Of Advanced Biomedical Engineering And Science Tokyo Women&a
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Kawamoto Manabu
Institute Of Rheumatology Tokyo Women's Medical University
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Kanzaki Hideaki
Division Of Cardiology National Cardiovascular Center
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Kanzaki Hideaki
Department Of Cardiology National Cardiovascular Center
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Abe Hiroshi
Department Of Cardiology National Cardiovascular Center
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Kitakaze Masafumi
Division Of Cardiology National Cardiovascular Center
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Kitakaze Masafumi
国立循環器病センター 心臓血管
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Kitakaze Masafumi
Nagoya University Graduate School Of Medicine
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Kitakaze Masafumi
Department Of Cardiology National Cardiovascular Center
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Hasegawa Takuya
Cardiovascular Division of Medicine
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Takahama Hiroyuki
Department of Cardiology, National Cardiovascular Center
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Muro K
国立がんセンター中央病院
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Muro Kei
Gastrointestinal Oncology Division National Cancer Center Hospital
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Kim Jyonjoon
Cardiovascular Division Of Medicine National Cardiovascular Center
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Kim Jiyoong
国立循環器病センター 心臓血管内科
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Kim Jiyoong
Department Of Cardiology National Cardiovascular Center
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Mano Akiko
Department Of Organ Transplantation National Cardiovascular Center
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Manabe Kasumi
鳥取大学 医学系研究科再生医療学
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Kitakaze Masafumi
Division Of Cardiovascular Medicine National Cardiovascular Center
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Abe Hiroshi
Cardiovascular Division Osaka Minami Medical Center
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Asanuma Hiroshi
Departments Of Cardiology Chubu Rosai Hospital
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Katoh Masahiko
日本大学医学部附属駿河台病院 循環器科
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Yoshida Akemi
Cardiovascular Division Of Medicine National Cardiovascular Center
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Kanzaki Hideaki
Division Of Cardiovascular Medicine National Cardiovascular Center
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Hasegawa Takuya
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Kitakaze Masafumi
大阪大学 第1内科
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Kimu Jiyoong
国立循環器病センター
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Asanuma Hiroshi
Department Of Cardiology National Cardiovascular Center
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Takahama Hiroyuki
Cardiovascular Division Of Medicine National Cardiovascular Center
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Funada Akira
Department Of Cardiology Ishikawa Prefectural Central Hospital
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Kawashiri Masa-aki
金沢大学 医学系研究科循環医科学専攻
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Minatoya Kenji
国立循環器病センター 心臓血管外科
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Kajikawa Mariko
ABLE Corporation
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Yokoyama Hiroyuki
Cardiology And Emergency Medicine National Cardiovascular Center
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Abe Hiroshi
Institute Of Symbiotic Science And Technology Tokyo University Of Agriculture And Technology
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Amaki Makoto
Division Of Cardiology National Cardiovascular Center
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Amaki Makoto
Department Of Cardiology National Cardiovascular Center
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Matsushita Aya
Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University
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Kakihara Masako
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Kawamura Mihoko
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Manabe Kasumi
Division Of Cardiovascular Medicine National Cardiovascular Center
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Amemiya Hiroshi
Dept. Of Radiology And Surgical Research National Cardiovascular Center
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Abe H
Institute Of Symbiotic Science And Technology Tokyo University Of Agriculture And Technology
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Kuzuya Masafumi
Department Of Geriatrics Nagoya University Graduated School Of Medicine
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Abe H
Department Of Cardiology National Cardiovascular Center
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Manabe Kasumi
Division Of Regenerative Medicine And Therapeutics Department Of Gene Therapy And Regenerative Medic
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Chen Chun-yen
Department Of Chemistry National Cheng Kung University
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Asakura Masanori
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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Kitakaze Masafumi
First Department Of Medicine And Department Of Pathophysiology Osaka University School Of Medicine
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Kadoma Masaaki
The First Department Of Medicine Osaka University School Of Medicine
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Yokoyama Hiroyuki
Department Of Biology Faculty Of Science Niigata University
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Abe Hiroshi
1st Dept. Of Intern. Med. Osaka Univ. Med. School
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Asano Hiroyuki
Department Of Cardiology Chiousha Iwakura Hospital
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Abe Hiroshi
Central Laboratory.osaka University Medical School.
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Kanzaki Hideaki
Cardiovascular Division Of Medicine National Cardiovascular Center
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YOSHIDA Akemi
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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Chen Chun-yen
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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Yokoyama Hiroyuki
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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Yoshida Akemi
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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Funada Akira
Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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