Stimulating Macrophage Activity in Mice and Humans by Oral Administration of Quillaja Saponin

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概要

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• Quillaja saponin (QS) was examined for its immunostimulating effect on mice and humans after oral administration. Mice fed QS for 24 h significantly increased in chemotactic and phagocytosis activities of peritoneal macrophages. This enhancing effect in both activities continued for 4-d after QS administration. Mice fed QS for 24 h prior to an interperitoneal challenge with Escherichia coli showed a higher survival rate than the control group. Peripheral blood analysis of volunteers showed significant increases in chemotactic and phagocytosis activities after oral administration of QS for 7 d. Furthermore, the volunteers did not show significant changes in immunoglobulin, transaminase, IL-1α, or TNF-α levels, or in serum albumin concentrations. Thus orally administered QS can effectively enhance the immune response through stimulation of macrophages without adverse effects.

• 2011-10-23

著者

• Hatta Hajime

  Department Of Food And Nutrition Kyoto Women's University

• Naknukool Supaporn

  Department Of Applied Biological Science Faculty Of Agriculture Kagawa University

• Horinouchi Izumi

  Department Of Food And Nutrition Kyoto Women's University

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