Generation of Functional Monocyte-Derived Dendritic Cells from HTLV-I Infected Rabbits : Therapeutic Approach Using a Dendritic Cell Vaccine
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概要
- 論文の詳細を見る
Dendritic cells (DC) are essential antigen-presenting cells (APC) with a unique capacity to initiate an immune response. We described the in vitro generation of rabbit monocyte-derived DC (Mo-DC) in the presence of granulocyte macrophage-colony stimulating factor and interleukin-4. Autologous DC, which had phagocytosed apoptotic Ra-1 cells, acted as an APC for cellular response following their injection into human T lymphotropic virus type I (HTLV-I)-infected rabbits. PKH-26 labeled DC preferentially homed to the T cell area of the draining lymph node following s. c. injection, whereas i. v. -injected DC accumulated in the spleen. We demonstrated that rabbit Mo-DC functioned as potent APC in vivo and that the route of DC administration was inconsequential for cytotoxic T lymphocytes response. Although Mo-DC generated from patients with adult T-cell leukemia/lymphoma (ATLL) show a functional impairment, this study provides evidence that a new, supporting immunotherapy using the donors DC generates a more efficient anti-HTLV-I infected cell/ATLL cell immune response following allogeneic stem cell transplantation.
- 日本リンパ網内系学会の論文
- 2004-04-01
著者
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Hirouchi Takashi
Departments Of Diagnostic Pathology Kochi Red Cross Hospital
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Taguchi Hirokuni
Third Department Of Internal Medicine Kochi University School Of Medicine
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武本 重毅
高知医科大学第三内科
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武本 重毅
熊本大学医学部第二内科
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MACHIDA Hisanori
Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University
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Taguchi Hirokuni
Department Of Diagnostic Pathology Kochi Red Cross Hospital
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Furuya Masato
Institute For Laboratory Animals Kochi Medical School
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Muneishi Hidenori
Third Department Of Internal Medicine Kochi Medical School
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Iguchi Mitsuko
Department Of Hematology And Respiratory Medicine Kochi Medical School Kochi University
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Miyoshi Isao
Department Of Hematology And Respiratory Medicine Kochi University School Of Medicine
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Miyoshi Isao
The Third Department Of Internal Medicine Kochi Medical School
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Hamauzu Tadashi
Department Of Pathology And Laboratory Medicine Kochi Red Cross Hospital
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Takemoto Shigeki
Department Of Hematology And Respiratory Medicine
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AL-DAHOODI Ziyad
Department of Hematology and Respiratory Medicine
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Miyoshi Isao
Third Department Of Internal Medicine Kochi University School Of Medicine
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Furuya Masato
Institute Of Laboratory Animals Kochi Medical School
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Taguchi Hirokuni
Department Of Hematology And Respiratory Medicine
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FURUYA Masato
Institute for Laboratory Animals
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